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The aim: To determine the dynamics of changes in metric parameters of the duct system of rat submandibular glands in normal conditions and chronic ethanol intoxication. Materials and methods: 50 albino outbred rats were involved in the experiment. 10 animals were assigned in the control group, 40 animals – in the experimental group. Animals were sacrificed on 5, 9, 12 and 30 days by overdose of thiopental anesthesia. Pieces of the submandibular glands were embedded into epon-812 according to the conventional technique. Results: On day 5 of the experiment the lumen diameter of intercalated duct reduced by 9,15 % (р <0,05). The lumen diameter of the striated ducts was by 5,29 % significantly greater than the values in controls (р <0,05). The lumen diameter of the granular ducts reduced by 2,45 % (р <0,05). On day 30 of the experiment the height of the epithelial cells of the intercalated ducts was by 8,47 % significantly less (р <0,05), the height of the epithelial cells of the striated ducts was by 12,27 % less (р <0,05) and the height of the epithelial cells of the granular ducts was by 11,96 % less (р <0,05) than the values in controls. Conclusions: No recovery of parameters occurs by day 30 of the experiment, indicating the depletion of the secretory epithelium of the duct system, due to dystrophic changes caused by vascular disorder in the microvasculature.

Introduction: Polymeric substances, which are used in medicine, can lead to the development of pathological conditions. Therefore, in toxicological evaluation of polymeric materials for medical purposes the primary task is the creation of the appropriate adequate methods of study. The aim: To study the acini of the rats’ submandibular salivary glands in normal condition and after exposure of 1% methacrylate. Material and methods: Were studied 50 white rats during the influence of 1% methacrylate on the mucosa of the oral cavity. Histological sections of the rats’ submandibular salivary glands in normal condition, on day 14 and 30 of experiment were studied using the UMPT – 7 ultramicrotome of Sumy PA “Selmi”. Results and conclusions: The morphometric study has established that in control group the values of the outer diameter of the submandibular glands’ acini, the diameter of the lumen and the height of the acini epithelial cells was 36,27±2,17 μm, 9,47±0,63 μm and 14,18±1,05 μm, respectively. Histological specimens showed that the acini cells had a prominent basophilia of the cytoplasm and the basally located nucleus. Numerous large homogeneous granules were located in the apical pole of the cells. After influence of the 1% methacrylat there is an increase in the activity of secretory cells, which is confirmed by an increase in the height of epitheliocytes by 25.04% and is a compensatory metacrylate reaction. The increase in salivation further leads to complete depletion of the secretory apparatus of the seromucosal cells, which is confirmed by a decrease in the outer and inner diameters with a decrease in the height of the mandibular salivary glands acini cells by 24.40%.

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The purpose of the study was to reveal the theoretical foundations of the implementation of the tutoring approach to the teaching of histology, cytology and embryology as a universal pedagogical technology. Materials and methods. Analyses, generalization and systematization of information from scientific and methodical literature were used in the study. Results and discussion. Tutoring technology is one of the credit-module system of education components in educational institutions of the III-IV levels of accreditation. Individualization of education contributed to the development of tutoring technologies, which are aimed at the development of independent work in the educational process of a higher medical school, and the tutor is responsible not only for the level of knowledge, but also for the formation of the personality of the future doctor. The introduction of tutoring into the educational process is a desire to identify the gifted young generation, to help them organize themselves in the educational space of the university and to get to know the applicants with their dreams and problems. The tutor gradually acquires a different role from previous work experience, which requires mastering self-organization techniques, the ability to take the initiative in a situation of uncertainty, and the cultivation of paradoxical thinking. The tutor becomes a role model, showing students certain orientations and techniques for self-improvement. Implementation of tutoring in a higher medical school takes place on the basis of mutual respect and trust, which creates a real opportunity for continuous professional growth of the teacher's competence and increasing the knowledge of students, their self-esteem, forms of flexibility and non-standard thinking, creates a desire to replenish one's own knowledge. Tutoring is one of the promising directions of the development of the individualization of training in the professional training of future medical students, which contributes to: creation of a whole set of educational and teaching-methodical manuals for independent work; development of integrated interdepartmental tasks; development of collegial relations of teachers and students; development of tasks that involve non-standard solutions. Conclusion. Tutoring is one of the forms of organizing the educational process, which involves mostly individual consultations, the use of project methods, and the introduction of information technologies. It helps to form the skills of self-education, self-development and creative solution of professional tasks, training in effective methods of development and implementation of research projects in various spheres of practical activity of students