Results of complex research of features of clinical and immunological profiles tick-borne encephalitis during the sharp period in Tomsk Region are resulted in the article. Last years redistribution of a parity of clinical displays of the sharp period in favor of prevalence of feverish forms of disease and a tendency to increase in cases of long circulation of an antigene of a virus tick-borne encephalitis is marked. One of the important reasons of such effect is decrease in immunological reactance of an organism with development of cytokine’s disbalance and expression infringement receptors of cytokines with lymphocytic cages.

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Research of influence of recombinant tumor necrosis factor alpha, interleukin-2 and interleukin-4 in vitro on the apoptosis of lymphocytes is performed. It is revealed that a proapoptotic effect of these cytokines is dose-dependent and is realized with the assistance of reactive oxygen species and mitochondrias.

The analysis of gene polymorphism plays an important role in assessment of disposition to infectious diseases at the population and individual level. In this paper, the frequencies of allelic versions of apolipoprotein E and 2nd type superoxide dismutase genes and the corresponding genotypes were determined in healthy persons and chronic viral hepatitis type C patients of the Europeoid population of the Tomsk Region. For the analysis of polymorphism of these genes, we used modern genetic methods: polymerase chain reaction and polymorphism of lengths of restriction fragments. For the studied population, it was revealed that the polymorphism of apolipoprotein E and 2nd type superoxide dismutase genes correlates with the development of chronic viral hepatitis type C and with the fibrogenesis process.

For detection of cytokine production features in patients with development of chronic tick-borne borreliosis the evaluation of spontaneous, fitohaemagglutinin-stimulated and stimulated with antigen of borrelia cytokine production was conducted in supernatants of three-day blood cells cultures. High risk of development of chronic tick-borne borreliosis associated with intensive spontaneous and antigen-stimulated production of interferon-g and transforming growing factor-β1 in acute disease.