Results of complex research of features of clinical and immunological profiles tick-borne encephalitis during the sharp period in Tomsk Region are resulted in the article. Last years redistribution of a parity of clinical displays of the sharp period in favor of prevalence of feverish forms of disease and a tendency to increase in cases of long circulation of an antigene of a virus tick-borne encephalitis is marked. One of the important reasons of such effect is decrease in immunological reactance of an organism with development of cytokine’s disbalance and expression infringement receptors of cytokines with lymphocytic cages.

In this article results of the clinical-immunological analysis with different forms tick-borne encephalitis of Tomsk Region during the period from 2000 to 2008 are represented. The revealled disbalance of cytokines alongside with breach of the expressions cytokines's receptor by limphocytes's cells, can be one of the main of the reasons to inefficiency answer when introducing the infectious agent in organism and shaping the chronic form to infectious pathology, in particular, with long presence of the antigen of the virus tick-borne encephalitis in blood. The trend to increase the level sick with long presence of the antigen of the virus tick-borne encephalitis in blood, with prevalence of the persons feminine flap, mainly average and senior age for the last years is given.

A comparative analysis of neurological manifestations in patients with acute ixodic tick-borne borreliosis (ITB) and patients with ITB associated with chronic opisthorchiasis has been carried out. It has been found that at ITB in the acute phase, nearly all parts of the nervous system are involved in the pathological process. Diseases of central parts of the nervous system were found in 86.7% patients with the monoinfection and in 96.7% patients with ITB associated with chronic opisthorchiasis, diseases of the vegetative part were found in 75.0 and 83.3% patients, and peripheral failures were found in 18.3 and 48.3% patients, respectively. In the structure of neurological pathology of the acute stage of ITB with chronic opisthorchiasis, the prevalence of the combined disease of different parts of the nervous system (93.3%), the more frequent occurrence (96.7%) and higher intensity of headaches (more than 4 points by the visual analog scale), vertigo (76.7%), cognitive failures (35.0%), signs of the vegetative disfunction syndrome (95.0%), and peripheral neuropathy (48.3%) were diagnosed.

In the given work had been lead the analysis of epidemiological data TBE for 1999—2009 on Tomsk area. The information on quantity imparted against tick-borne encephalitis, about results of research of pincers and blood at the persons who have addressed on points prevention of tick-borne encephalitis and about quantity of the diseased tick-borne encephalitis is presented. Analysis of a complex of preventive actions is spent. The reasons of formation of the long maintenance of a virus tick-borne encephalitis in blood are shown.

The results of the study outcomes of tick-borne encephalitis in adults in the Tomsk Region. Patients conducted a comprehensive clinical and laboratory examination. Revealed the prevalence of autonomic disorders in individuals who have had at different periods of tick-borne encephalitis, which is regarded as the effects of tick-borne infection. Residual effects of tick-borne encephalitis occurs mainly in the form of light paresis after suffering a focal forms. Among the chronic (progredient) forms of tick-borne encephalitis often formed hyperkinetic options. Most of the study revealed the presence of precipitating factors that could have an influence on the outcome. Fundamental diffe rences in all-clinical and immunological analyses at patients with various outcomes of tick-borne encephalitis it wasn't noted. KEY WORDS: tick-borne encephalitis, Tomsk Region, the outcomes.