Results of complex research of features of clinical and immunological profiles tick-borne encephalitis during the sharp period in Tomsk Region are resulted in the article. Last years redistribution of a parity of clinical displays of the sharp period in favor of prevalence of feverish forms of disease and a tendency to increase in cases of long circulation of an antigene of a virus tick-borne encephalitis is marked. One of the important reasons of such effect is decrease in immunological reactance of an organism with development of cytokine’s disbalance and expression infringement receptors of cytokines with lymphocytic cages.

The results of the study outcomes of tick-borne encephalitis in adults in the Tomsk Region. Patients conducted a comprehensive clinical and laboratory examination. Revealed the prevalence of autonomic disorders in individuals who have had at different periods of tick-borne encephalitis, which is regarded as the effects of tick-borne infection. Residual effects of tick-borne encephalitis occurs mainly in the form of light paresis after suffering a focal forms. Among the chronic (progredient) forms of tick-borne encephalitis often formed hyperkinetic options. Most of the study revealed the presence of precipitating factors that could have an influence on the outcome. Fundamental diffe rences in all-clinical and immunological analyses at patients with various outcomes of tick-borne encephalitis it wasn't noted. KEY WORDS: tick-borne encephalitis, Tomsk Region, the outcomes.