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We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by α ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.

Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were greater in the hindbrain, including the cerebellum (34.8%), than in the hemispheres, including the thalamus, hypothalamus, hippocampus, and cortex (18.0%).

The increase of hyaluronic acid concentration in the blood serum of rats during modelling of chronic hepatitis C is presented. The research of changes in the absolute and relative hyaluronate-binding activity of cytosolic proteins in the rats’ cerebellum and hippocampus under normal condition, experimental chronic hepatitis C and with the alfa-ketoglutarate treatment was carried out.