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The aim of this study was to evaluate, in vitro, frictional forces produced by ceramic brackets and arch wires of different alloys. Frictional tests were performed on three ceramic brackets: monocrystalline (Inspire ICE), polycrystalline (InVu), polycrystalline with metal slot (Clarity), and one stainless steel bracket (Dyna-Lock). Thirty brackets of each were tested, all with .022" slots, in combination with stainless steel and nickel-titanium wires .019" × .025", at 0° and 10° angulation, in artificial saliva. Arch wires were pulled through the slots at a crosshead speed of 10 mm/min. There were statistically significant differences between the groups of brackets and wires studied (p < .05). The polycrystalline brackets with metal slots had values similar to those of conventional polycrystalline brackets, and the monocrystalline brackets had the highest frictional forces. The nickel-titanium wires produced the lowest friction. The addition of metal slots in the polycrystalline brackets did not significantly decrease frictional values. Nickel-titanium wires produced lower friction than those of stainless steel.