The correlation of values of CD4 Count, platelet, PT, APTT, fibrinogen and factor viii was carried out. One hundred and sixty four subjects were sampled, comprising one hundred and fourteen HIV positive subjects and fifty HIV negative subjects which served as the control. PT, APTT, Fibrinogen, Factor VIII, Platelet and CD4 count were analyzed using standard techniques. The results showed that HIV positive subjects had a significantly lower CD4 count (360.00±107.09) and Platelet count (157 ± 98.40) when compared with the HIV negative subjects (940 ± 220.05) and (228 ± 62.04) respectively. Also PT and APTT were significantly higher (P<0.05) in HIV positive subjects (19.56 ± 3.14) and (42.86 ± 7.10) respectively when compared with the HIV negative subjects (14.90 ± 1.91) and (37.90 ± 3.98) respectively. Whereas, there were no significant changes (P> 0.05) in fibrinogen and factor viii concentration between the HIV Positive subjects and the HIV negative subjects. Among the HIV positive subjects, platelet count did not differ significantly (p> 0.05) between those with CD4 count < 200 cells/µl and those with CD4 count ≥ 200 cells/ µl. However, PT and APTT showed significant changes (22.40 ± 2.96) and (48.20 ± 8.01) respectively, in HIV Positive subjects with CD4 count <200 cells/µl. Furthermore, there were positive correlation between PT and APTT, PT and CD4 count, APTT and CD4 count, Platelet and CD4 count (P<0.01) respectively while there were no correlation between other coagulation parameters tested(P > 0.01).

The effect of viral hepatitis on some coagulation parameters APTT, PT,TT,Fibrinogen and platelets were determined among blood donors at FMC Umuahia. One hundred and sixty three blood donors were sampled comprising One hundred and thirteen as follows; (HAV 16, HBV 65 and HCV 32) and fifty non hepatitis subjects who served as control. The parameters were analysed using standard haematology technique. Results obtained showed no statistical significant changes in the coagulation parameters in HAV subjects (32.8±2.6) secs, 12.4±1.5 (secs), 16.7±1.3 secs, 2.9±0.2g/L and 249±73 10 9 /L when compared with control group 34.1±3.1 secs 13.4±1.7 secs 16.7±1.5 secs 2.5±0.6g/L and (263±74) 10 9 /L respectively for the parameters as stated above (P > 0.05), significant change in HBV infection 42.4±5.8 (secs); 22.3±10.7 (secs); 23.9±4.7 (secs); 1.8±1.1(g/L); and 162±144(10 9 /L) when compared with the control 34.1±3.1 (secs); 13.4±171 (secs); 16.7±1.5 (secs); 2.5±0.6 g/L); 26. ±74 (10 9 /L) respectively at P<0.05. The HCV infection showed the same significant changes in all the coagulation factors estimated; 45.0±6.3 (secs); 20.9±4.9 (secs); 24.6±5.6 (secs); 1.6±0.6 (g/L) and 170±61 (10 9 g/L) when compared with the same control group. The APTT showed a positive relationship with PT and TT and a negative relationship with fibrinogen and platelets. PT had a strong positive correlation with TT and a negative relationship with fibrinogen and platelet. TT showed a strong negative relationship with fibrinogen and platelet. The result showed an alteration in the levels of coagulation factors following viral infection of the liver.

No abstract

The effect of age on prothrombin time (PT) activated partial thromboplastin time (APTT) andplatelet count (PC)

The study was carried out in Living Word Mission Hospital, Abayi, Aba, Abia State, Nigeria.The study was carried out among the ART and non-ART HIV patients attending the hospital.The CD4 count values were compared among the ART and the non-ART HIV patients to ascertain if there is any significant change among those on treatment and those not receiving treatment. The total number of subjects for the study was 97 (female=68, male=29). 77 subjects were ART HIV patients (female=55 and male=22) while 20 subjects were non-ART HIV patients (female=14 and male=6).The study showed significant increase (P<0.05) in the CD4 count of ART HIV patients more than non-ART HIV patients. The study equally showed significant increase (P<0.05) among the female ART HIV patients compared to the male ART HIV patients.The study showed that CD4 count should be done early to know when to start the treatment and the antiretroviral drugs have significant improvement in the immune system of the patients particularly the females.