The Correlation of Values of Cd4 Count, Platelet, Pt, Aptt, Fibrinogen and Factor VIII Concentrations among HIV Positive Patients in FMC Owerri

Abstract

The correlation of values of CD4 Count, platelet, PT, APTT, fibrinogen and factor viii was carried out. One hundred and sixty four subjects were sampled, comprising one hundred and fourteen HIV positive subjects and fifty HIV negative subjects which served as the control. PT, APTT, Fibrinogen, Factor VIII, Platelet and CD4 count were analyzed using standard techniques. The results showed that HIV positive subjects had a significantly lower CD4 count (360.00±107.09) and Platelet count (157 ± 98.40) when compared with the HIV negative subjects (940 ± 220.05) and (228 ± 62.04) respectively. Also PT and APTT were significantly higher (P<0.05) in HIV positive subjects (19.56 ± 3.14) and (42.86 ± 7.10) respectively when compared with the HIV negative subjects (14.90 ± 1.91) and (37.90 ± 3.98) respectively. Whereas, there were no significant changes (P> 0.05) in fibrinogen and factor viii concentration between the HIV Positive subjects and the HIV negative subjects. Among the HIV positive subjects, platelet count did not differ significantly (p> 0.05) between those with CD4 count < 200 cells/µl and those with CD4 count ≥ 200 cells/ µl. However, PT and APTT showed significant changes (22.40 ± 2.96) and (48.20 ± 8.01) respectively, in HIV Positive subjects with CD4 count <200 cells/µl. Furthermore, there were positive correlation between PT and APTT, PT and CD4 count, APTT and CD4 count, Platelet and CD4 count (P<0.01) respectively while there were no correlation between other coagulation parameters tested(P > 0.01).

Basic Coagulation Parameters among Human Immunodeficiency Virus-Infected Adults in Gondar, Northwest Ethiopia: A Comparative Cross-Sectional Study

“…This finding was concordant with the studies done in Jimma town of Ethiopia, Abia state city of Nigeria, and Benin city of Nigeria which found significantly prolonged PT, APTT, and INR in HIV-infected individuals compared to controls [28, 36, 37]. Similarly, studies conducted in Owerri and Anambra also found significantly high PT and APTT in infected adults ( P < 0.05) [7, 29]. HIV infection has been associated with endothelial dysfunction, liver disease, and factors predisposing for hypercoagulable state including the presence of antiphospholipid antibodies and lupus anticoagulant, and deficiencies of protein C and protein S which cause activation and consumption of coagulation factors might be the possible reason for the occurrence prolonged PT and APTT in HIV-infected individuals [15, 27, 38–40].…”

“…Moreover, at the low CD4 count, HIV-associated endothelial activation and liver damage are common complications [48]. Endothelial activation and liver damage cause consumption of blood clotting factors and/or abnormal production of liver-dependent clotting factors that can result in the occurrence of prolonged APTT in HIV-infected adults [7]. …”

“…There are different factors that affect the normal hemostatic system, of which HIV infection is known to have been one of the main causes of hemostatic abnormality [7]. HIV infection causes serious haemostatic complication especially in the late stage of HIV infection, as immune suppression, and the presence of concurrent infection or neoplastic diseases exacerbates the condition [8].…”

The Correlation of Initial CD4 Cell Count with Increased Alanine Aminotransferase in Patients with Human Immunodeficiency Virus Who Have Received Nevirapine

“…CD4 count is used to determine the stage of HIV disease, the risk of opportunistic infections, to assess the prognosis, measure immunity status and as a guide to decide when to start ART (Itodo GE, 2015;Leticia OI, 2014). Generally, a person with normal immune status has a CD4 count of 800-1,200 cells/μL of blood.…”

Trends and Adaptive Optimal Set Points of CD4+ Count Clinical Covariates at Each Phase of the HIV Disease Progression

“…Previously suggested covariates of the CD4 + count from different clinical categories include the full blood count [20][21][22][23][24][25][26], lipids [27][28][29], sugar [30][31][32], blood chemistry [21,[33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50], and clinical examination measurements [51][52][53][54][55][56][57][58][59][60].…”