Annually, more than 1 million premature infants die of infectious diseases due to the failure of the mechanisms of antiviral and antibacterial protection. In this regard, immune build up with timely vaccination to prevent severe infections is a particularly important factor. This study presents a retrospective analysis of the results of vaccination of extremely premature infants. The results of immunization were analyzed, and the vaccination scheme for children born with very low and extremely low body weight are presented.