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How to cite this paper: Makki, M.S.T., Rahman, R.M.A. and Ali, O.A.A. (2015) Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone. International Journal of Organic Chemistry, 5, 153-165. http://dx.Abstract Some new fluorinated 3-N-acyl/3-N-alkylaminophenyl-1,2,4-triazino[3,4-b][1,3,4]thiadiazolones (2-12) have been obtained from treatment of 2-(4'-fluorophenyl)-6-(2'-amino-5'-fluorophenyl)- 1,2,4-triazino[3,4-b][1,3,4]thiadiazol-4-one(1) with active functional oxygen, sulfur and halogen compounds in different conditions. Former structures of the products have been characterized from elemental and spectral data (UV, IR, NMR and Mass). The new products were evaluated as potential anthelmintic drugs.

Synthesis of some new full fluorinated heterobicyclic nitrogen systems containing 1,2,4-triazine moiety (4-10) have been deduced from heterocyclization of 6-(2'-trifluoroacetylamino)phenyl-3-(4'-fluorophenyl-1,2,4-triazin-5-one (3) with active oxo / halo-compounds. Structure of the products have been established upon their elemental and spectral date. Most of these systems exhibited a good to moderate antifungal activities.