Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone

Abstract

How to cite this paper: Makki, M.S.T., Rahman, R.M.A. and Ali, O.A.A. (2015) Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone. International Journal of Organic Chemistry, 5, 153-165. http://dx.Abstract Some new fluorinated 3-N-acyl/3-N-alkylaminophenyl-1,2,4-triazino[3,4-b][1,3,4]thiadiazolones (2-12) have been obtained from treatment of 2-(4'-fluorophenyl)-6-(2'-amino-5'-fluorophenyl)- 1,2,4-triazino[3,4-b][1,3,4]thiadiazol-4-one(1) with active functional oxygen, sulfur and halogen compounds in different conditions. Former structures of the products have been characterized from elemental and spectral data (UV, IR, NMR and Mass). The new products were evaluated as potential anthelmintic drugs.

Synthetic Approach for Novel Fluorine Substituted <i>α</i>-Aminophosphonic Acids Containing 1,2,4-Triazin-5-One Moiety as Antioxidant Agents

“…Phosphorus compounds bearing and/or containing 1,2,4-triazine moieties exhibit a significant attention due to the specific biological properties [13] [14] [15] [16] [17]. Also, the introduction of fluorine atoms to heterocyclic nitrogen systems, mostly improve their physical, chemical and medical properties [18] [19] [20] [21]. In the present work, we focused on the reactivity of functional 1,2,4-triazines towards different reagents followed by simple addition of diethyl phosphonate to obtain a novel fluorine substituted α-amino phosphonic acids which considered as α-amino acids analog, in view of antioxidant activity.…”

Synthesis and Antifungal Activity of Some New Fluorine-Substituted 4-Thiazolidinone Bearing 1,2,4-Triazinone

“…On the other hand, functionally 1,2,4-triazine derivatives have essential properties as medicinal, pharmacological and biological fields [4] [5] [6]. Also, the introduction of fluorine atom to the heterocyclic systems often enhances and improves their properties [7] [8] [9].…”

Regioselective Green Synthesis and Antimicrobial properties of full fused non mixed Heterocyclic Systems

“…Therefore, a lot of heterocyclic systems attitude 1,2,4triazines are found to have significant pharmacological effects [6][7][8][9][10][11][12][13] . That targets have anti-AIDS 14,15 , antiviral 16 , anticancer [17][18][19][20] , antimicrobial [21][22][23][24] , antitumor 25 , antithelmintic drugs 26 . The nature of substituent in 1,2,4-triazines have prompt affect on the orientation of cyclization reaction 27 , so that the substituted at position 6 of 3-hydrazino-5-hydroxy-1,2,4-triazine effect on the orientation of cyclization to form 1,2,4-triazolo [1,2,4]triazines.…”