New cisplatin analogue Pd(ii) and Pt(ii) complexes bearing charged pyridylbenzimidazole derivatives furnished with either an alkylated sulfonate or a phosphonium side chain were synthesized, fully characterized and tested for their antimicrobial and cytotoxic activities against noncancerous human embryonic kidney cells (HEK293). The interactions with CT-DNA were investigated using UV/vis spectroscopy. Assignment of the electronic transitions was performed with the aid of TDDFT. The complexes showed interesting antifungal activity against Candida albicans and Cryptococcus neoformans. The Pd(ii) complex conjugated with alkylated triphenylphosphonium exhibited higher cytotoxicity (CC = 8.932 μg mL, equivalent to 12 nM) than the others. The reactivity towards hen egg white lysozyme (HEWL) was investigated by electrospray ionization mass spectrometry. The formation of DNA- and HEWL-adducts was achieved via the noncovalent and covalent interactions.

No abstract

The photoinduced CO-releasing properties of [RuL Py (CO) 2 Cl 2 ] (1), [Ru(L Py2Bz -ĸ 2 N 1 ,N 2 )(CO) 2 Cl 2 ] (2), and [Ru(L Py2Bz-Et -ĸ 3 N 1 ,N 2 ,N 3 )(CO) 2 (Cl)]·PF 6 (3) [L Py = 2-(2-pyridyl)benzimidazole, L Py2Bz = 2,6-bis(benzimidazole-2′-yl)pyridine, and L Py2Bz-Et = 2,6-bis(1-ethyl-benzimidazol-2′-yl)pyridine] in both DMSO and reduced myoglobin solution are reported. Complexes 1 and 2 release CO upon illumination at 365 nm. The bidentate chelation mode of L Py2Bz in 2 is changed into a meridional tridentate mode upon the ethylation of the benzimidazolic NH groups, 3. The extension of the conjugation system and the shift of the MLCT band into the visible region in 3

[a] 1IntroductionIodide is necessary for human health as it guarantees the proper thyroid gland function and it is used as antiseptic for skin wounds.I odidea lso exists in food, drug compound and in drinking water and it is added to table salts as as upply of iodine to prevent iodine shortage disorders [1].I na ddition, it is used as catalyst or stabilizer in polymer production and as purifying agent of drinking and swimming pool waters. Therefore,d etermination of iodide in the field of food, biological, and environmental samples is of vital importance.F or this purpose,m any methods have been developed, among of them potentiometric basedi on selective electrode methodw hich offers speed determination, ease of preparation,f ast response time,w ide working linear range,f air selectivity,a nd low cost.Anion-selective electrodesb ased on lipophilic quaternary ammonium or phosphonium saltse xhibit Hofmeister selectivity pattern that is basedo na nionl ipophilicity. Thus,t he construction of anion potentiometric sensors based on new metal complexes which display non-Hofmeister selectivity pattern is an attractive pointo fr esearch in the field of chemical sensors.T he selectivity manner of theses ensors towards anions is found to be influenced by the steric effect related with the structure of ligandsa nd the properties of the central metal ions [2][3][4] where ad irect interaction occurs between the central metal of the membrane active components and the analyte anion. [14] in various matrices including polyvinyl chloride and carbon paste.T ot he best of our knowledge,t here is only one published paper on the use of screen printed electrode for iodided etermination [15]. Schiff bases are condensation products of primary amines with carbonyl compounds and they were first reported by Hugo Schiffi n1 864. Schiff bases have wide applications in foodi ndustry,d ye industry,a nalytical chemistry,c atalysis,f ungicidal, agrochemical and biological activities [16].T he transition metal complexes of Schiff-bases have been foundt os how attractive properties over the other ligands such as ease of preparation, formationo fh ighly lipophilic complexes,r emarkable biological and pharmacologicala pplications and the construction of different highly selective anion and environmental sensors,e nergy storage devices and solar cells [17][18][19][20].In this work, the synthesized Cu(II)-Schiff base complex (1) namely N-(4,6-Dimethyl-pyrimidin-2-yl)-4-[(2-hydroxybenzylidene)amino] benzene sulfonamidec opper-(II) dihydrated complex [21] (Fig.1)w as used as ionophore in polymeric membrane,c arbon paste,a nd screen printed electrodes.D ifferent compositions were studied, the selectivity behaviorw as examineda nd the electrodes were successfully applied for determination of iodide by ) and improved selectivity over the highly interfering thiocyanate were obtainedi nc omparisonw ith the previously reported Schiff base complexes-based iodide sensors.

No abstract