This study is the first to report on the larvicidal activity of the extracts of Cyclamen species against Culex pipiens. More studies are needed to isolate and identify the active components involved, their mode of action, and effects on other mosquito and pest species.

A new species of Helichrysum Gaertn., H. orbicularifolium Sümbül, R. S. Göktürk & O. D. Düşen sp. nov., is described and illustrated. The species is restricted to the south Anatolia Province, Antalya, Turkey, growing in humid calcareous rock crevices and on limestone cliffs. The species is compared with the closely related H. chasmolycicum. © 2003 The Linnean Society of London, Botanical Journal of the Linnean Society, 2003, 141, 251–254.

A new species from South Anatolia, Ornithogalum pamphylicum O.D. Düsen & H. Sümbül, is described and illustrated.

The modulatory effects of the Cyclamen trochopterantum tuber extract on hepatic drug-metabolizing enzymes, including aniline 4-hydroxylase (A4H; CYP2E1), ethoxyresorufin O-deethylase (EROD; CYP1A), methoxyresorufin O-demethylase (MROD; CYP1A), caffeine N-demethylase (C3ND; CYP1A2) aminopyrene N-demethylase (APND; CYP2C6), and erythromycin N-demethylase (ERND; CYP3A1), were examined in vivo in rats. The activities of all of these enzymes were induced by the cyclamen extract. In addition, Western-blot and RT-PCR results clearly showed that CYP2E1, CYP1A1/CYP1A2 and CYP2C6 protein and mRNA levels were substantially increased by four different doses of cyclamen. Although, the CYP3A1 protein level was increased significantly, the mRNA level was not changed. These results indicate that cyclamen tuber extract might have a potential not only to inhibit and/or induce the metabolism of certain co-administered drugs but also influence the development of toxicity and carcinogenesis due to the induction of the cytochrome P450-dependent drug-metabolizing enzymes

Morphological, anatomical and palynological properties of Cyclamen mirabile Hildebr. endemic to Anatolia, Turkey have been determined. Typifications, synonym lists, descriptions, ecology and phytogeography are provided for the species and its relationships to similiar species are discussed. The anatomical study from different plant parts of C. mirabile have been made for the first time. Its pollen morphologies were also defined. Morphological findings obtained in the present investigation were generally consistent with those given in the Flora of Turkey with some exceptions in numerical data.