The aim: To analyze the implementation of international standards ISO series, which ensures the creation of uniformity of measurements, the ability to use the results of laboratory studies to ensure their reliability and reproducibility. Materials and methods: The samples were taken from the ISO documents, the Regulation and the Quality Decree of clinical diagnostic laboratory (2017) that is the object of the research activities of the clinical diagnostic laboratory “City clinical hospital № 2 named after Prof. A. A. Shalimov”. Сonclusions: The introduction of international standards of the ISO series into the domestic laboratory practice ensures the creation of a single medical space, the uniformity of measurements, the possibility of using the results of laboratory studies with an increase in their reliability and reproducibility.