Background In contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity. Methods and results CLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia, and Africa in 2009–2010, and followed up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischaemia, or prior revascularization procedure. Among 32 694 patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to ∼60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome (cardiovascular death, myocardial infarction, or stroke) with an adjusted hazard ratio of 1.28 (95% confidence interval 1.18, 1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure, and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest. Conclusion In patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes. ClinicalTrials identifier ISRCTN43070564

Common diagnostic approach in patients with suspected cardiac amyloidosis includes cardiac magnetic resonance imaging and scintigraphy. We report the first clinical case of false‐positive results of scintigraphy in a patient with Danon disease.

Некомпактная кардиомиопатия левого желудочка (НКМЛЖ) представляет собой редкое заболевание сердца неишемической природы, характеризующееся повышенной трабекулярностью миокарда левого же-лудочка (ЛЖ) с наличием глубоких межтрабекулярных «карманов», ремоделированием его полости и постепенным снижением сократительной способности. Несмотря на появление в мировой литературе новых работ, посвященных клиническим проявлениям, диагностике и лечению НКМЛЖ, эта форма кардиомиопатии остается малоизвестной широкому кругу клиницистов. Учитывая крайне неблагоприятный прогноз для пациентов с НКМЛЖ, ранняя диагностика и своевременное начало лечения являются единственной возможностью для пациента снизить риск тромбоэмболических осложнений и проявлений сердечной недостаточности (СН). В настоящее время интерес к проблеме ранней диагностики НКМЛЖ среди кардиологов растет. Последнему способствует появление современных методов визуализации сердца, внедрение в широкую практику генетических методов исследования, и это позволяет надеяться на определение четких клинических, генетических и инструментальных предикторов неблагоприятного исхода у пациентов с НКМЛЖ в будущем и поз

Theory of mind is a cognitive ability, which enables to understand intentions, emotions and beliefs of another person. Because of theory of mind, people are able to interpret behavior of others and adapt to it. Numerous psychiatric impairments are associated with damaged theory of mind and communication with others. The present review analyses the impairments of theory of mind as laying on a continuum from hypermentalization (over-attribution of intentions to others) to hypomentalization (under-attribution of intentions to others) in autism spectrum disorders and schizophrenia. FMRI paradigm of different subprocesses of theory of mind is described (perceptual mind-reading, cognitive theory of mind, “hot” theory of mind and implicit theory of mind). Neural mechanisms of these subprocesses and their impairments in autism spectrum disorder and schizophrenia analyzed.

The opinion that COVID-19 is a greater threat only to the elderly people has changed over the past year. Experience has been accumulated in the development of complications of varying severity in young patients who had optimal health indicators before infection. The consequences of myocarditis are most dangerous, especially in athletes and military personnel. We present a series of clinical cases of spontaneous mitral valve chordae rupture in highly trained middle-aged men in the early post-COVID period. In all cases, the infection proceeded subclinically; SARS-CoV-2 was verified only by analysis for IgM. 1–2 weeks after infection, against the background of a routine training process, patients felt pain in the heart area, which was underestimated. Patients presented for help at 2 and 10 weeks with complaints of reduced endurance and shortness of breath. Echocardiography revealed rupture of one of the chords of the anterior part of the mitral valve against the background of signs of myocarditis with the development of valvular insufficiency of the 1st degree. By the time of treatment, the pathology of other laboratory data and ECG was not observed. The control after 6 months showed in 1 patient a focus of myocardial fibrosis according to MRI, a minimal increase in NT-proBNP, a decrease in exercise tolerance, in 2 patients there was no visible fibrosis, normal NT-proBNP and complete restoration of exercise tolerance, but a decrease in local myocardial deformation according to echocardiography.