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The theoretical substantiation of the search for potential medicinal products containing biologically active substances from the food plant raw materialConsidering that food plants have a stable raw material base and the proven safety to the human body the use of the raw material of food plants to create new medicines is relevant and has several advantages, such as a sufficient raw material base, significant efficiency and high safety level. Aim. To substantiate theoretically the search for potential medicinal products based on the food plant raw material, in particular carrot roots and parsnip roots. Materials and methods. Clinical and pharmacological analysis was conducted using the databases of scientific information (articles, monographs, abstracts of theses, etc.) from Ukraine and worldwide (NCBI, Vernadsky National Library of Ukraine, Google Scholar, Google Academy). This information contains data on the search, development, preclinical studies, clinical trials, application of medicinal products on the basis of the plant raw material, in particular carrot roots and parsnip roots, in officinal and folk medicine. Results. The study conducted has allowed us to prove the relevance, timeliness, expediency and prospect for searching new promising medicinal products on the basis of the raw material of food plants of the Apium genus -carrot and parsnip roots. Conclusions.The study has proven that the plants of the Apium genus -carrot and parsnip roots having a powerful, affordable and cheap raw material base are the sources of substances containing the amount of biologically active substances that are promising for the creation of new medicinal products on their basis with the cytoprotective, antiinflammatory, nephroprotective, wound healing, reparative action, and they are promising for introduction into medical practice for the treatment of skin lesions. Key words: biologically active substances; substances of plant origin; raw material from plants of Apium genus; carrot roots; parsnip roots Т. І. Єрмоленко, Н. С. Чорна, О. М. ШаповалХарківський національний медичний університет Теоретичне обґрунтування пошуку потенційних лікарських засобів, що містять біологічно активні речовини з сировини харчових рослин Зважаючи на те, що харчові рослини мають стабільну сировинну базу і доведену нешкідливість для організму людини, використання сировини харчових рослин для створення нових ЛЗ є актуальним та має низку переваг: достатню сировинну базу, значущу ефективність та високий ступінь безпечності. Мета. Теоретичне обґрунтування пошуку потенційних лікарських засобів на основі сировини харчових рослин, зокрема -коренеплодів моркви та пастернаку. Матеріали та методи. Клініко-фармакологічному аналізу підлягали джерела наукової інформації (статті, монографії, автореферати дисертаційних робіт тощо) з баз України та світу (NCBI, НБУ ім. В. І. Вернадського, Google Scholar, Google Академія), в яких наведені дані про пошук, розробку, доклінічні дослідження, клінічні випробування, застосування в офіцинальній та народній медицині ліка...

M., Kostenko V.O. Key words: systemic inflammatory response, acute gingivitis, modulators of redox-sensitive transcription factors NF-κB and Nrf2, quercetin, epigallocatechin-3-gallate, carbohydrate and lipid metabolism.The experiment on 70 white rats was designed to investigate the effects of a water-soluble form of quercetin and modulators of AP-1 and Nrf2 transcription factors on the blood indicators of the systemic inflammatory response (SIR), and carbohydrate and lipid metabolism under the conditions of intraperitoneal and intra-gingival administration of S. typhi lipopolysaccharide (LPS). The animals were divided into 7 groups: the 1st group consisted of intact rats; the 2nd group included animals exposed to combined systemic and local administration of LPS -pyrogenal; the 3rd, 4th and 5th groups included the animals who were respectively injected with watersoluble complex of quercetin and polyvinylpyrrolidone (corvitin) in a dose of 100 mg/kg (10 mg/kg in terms of quercetin), an inhibitor of activation of AP-1 SR 11302 (in a dose of 1 mg / kg) and Keap1 / Nrf2 / antioxidantresponsive element (ARE) signaling pathway inducer epigallocatechin-3-gallate (EGCG, in a dose of 21.1 mg / kg) 3 times a week, starting on the 30 th day since the experiment modeling. The 6th and 7th groups of the rats were subjected to combined effects of quercetin + SR 11302 and quercetin + EGCG, respectively. The study has demonstrated the combination of quercetin and SR 11302, or EGCG, in systemic and local administration of S. typhi lipopolysaccharide more effectively prevents the production of ceruloplasmin, a SIR marker, byproducts of lipid peroxidation in rats' blood, as well as increases its antioxidant potential compared to the separate application of these drugs. The combination of quercetin and SR 11302, or EGCG, under the experimental conditions has been found out to more effectively correct carbohydrate metabolism disorders (hyperinsulinemia, insulin resistance) than this occurs under separate usage of the agents, but does not reveal significant synergism in the correction of dyslipoproteinemia.