Microorganisms' resistance to antibacterial drugs is now a major threat to human health and public health. The aim of the work was to conduct a comparative study of the species composition and resistance to antimicrobial treatments of microorganisms isolated from patients during the pandemic of the new coronavirus infection in 2020 with that from patients in 2019. The work examined bacterial strains isolated from patients with bacterial complications from COVID-19 in the intensive care unit of the Infectious Diseases Center in 2020 and from patients of the same departments treated before the pandemic of new coronavirus infection in 2019. It has been found that the species composition and resistance of microorganisms, received from patients during the pandemic in 2020, differs from those received from patients of the same departments of the same hospital in 2019. The number of polyresistent and panresistent microorganisms has increased significantly, bacterial microflora redistributed to responsible bronchopulge complications, in biomaterial, including bronchoalveolar lavage, increased the number of yeast fungi. Monitoring of microbiological strains will allow us to analyze the structure of pathogens in a particular unit, levels of their resistance to antimicrobials, as well as to identify the distribution mechanisms of microflora. The findings will facilitate the prescribing of rational empirical antimicrobial therapy and the planning of proactive measures to prevent the spread of hospital infection.

Introduction International experience convincingly shows the prevalence of mental disorders secondary to COVID-19, the pathogenesis of which includes biological and psychosocial factors, which characterizes this area of research as relevant and timely. Objectives Analysis of the structure of the most common forms of psychopathology within consequences in COVID-19. Methods The study involved 45 patients with depressive episodes of varying severity (F 32.0, 32.1, 32.2) and 37 ones with anxiety disorders (F 40, 41). The average age of the examined groups was 39.42 ± 5.68 and 31.54 ± 4.36 years respectively. Clinico-psychopathological, psychodiagnostic, statistical methods were used. Results Significantly more patients with depressive disorders before the first clinical manifestations of the disease experienced COVID-19 in mild and moderate form (31.82% and 68.18% of individuals, respectively) (p <0.05), while patients with anxiety disorders were more affected to some stressors of the SARS-COV-2 pandemic (including threatening information background (83.78% of people), quarantine measures in the form of self-isolation (75.66% of people), uncertainty of the impact of coronavirus infection on the socio-economic situation) (62.16% of people)) (p < 0.05). It was found that the examined patients with a history of coronavirus COVID-19 are more likely to have depressive and asthenic syndromes in the clinical picture (p < 0.05), while patients with psychogenic effects of the pandemic - anxiety-phobic and somato-autonomic syndromes (p < 0,05). Conclusions Data on the influence of coronavirus disease COVID-19 and stressors of the SARS-CoV-2 pandemic on the formation of mental disorders of various genesis will allow to develop prevention algorithms and personalize therapeutic programs. Disclosure No significant relationships.

The coronavirus disease (COVID- 19) caused by the novel Coronavirus strain SARS-CoV-2 was firstly identified in December 2019 in China. Later on, in 3 months it got the status of a global pandemic. The coronavirus disease (COVID-19) posed a number of new challenges and questions for the population, medicine, and particularly for psychiatry. In many cases, it triggered a psychogenic beginning of mental, psychosomatic and somatic diseases. The initial pathogenesis of the mental diseases existing among the population has been complicated and sufficiently distorted due to COVID-19. In addition, it acts as the primary reason for the onset of many still unexplored and unknown illness processes, including mental diseases. Nowadays, the relevance of mental health plays an important role in personal, family, working, or social relationships. The rhythm of life and work in modern world demands stable mental health. It should be active, flexible, with sufficient reserve and rapid recovery. Some mental health disorders with the combination of increased information intensity and amount of communication links often lead even employable young people towards a deep lifelong disability. This pushes their active relatives, medical and social staff to their service. As consequence, these challenges pose a plenty of questions to society about the formation of family, parent and social relationships. As a result, COVID-19 and consequences caused by global pandemic require fast, adequate and in-time reaction from local and global societies. Retarded and unequal response can pose the humanity against diverse outcomes of this tragedy. To resume, it can sufficiently decrease the average level of human health all over the world.

<b>Introduction: </b>The purpose of the study was to investigate the mechanisms underlying COVID-19 (coronavirus disease 2019) pandemic and the ensuing health problems associated with quarantine.<br /> <b>Methods: </b>All combatants who were hospitalized during the first and most severe quarantine restrictions in Ukraine (from 12 March 2020 to 22 May 2020) were surveyed. Through clinical, anamnestic, psychopathological, and psychodiagnostic examination, including psychoanalysis and the fear of COVID-19 scale, the authors identified combatants’ health disorders and their association with pandemic and quarantine-related experiences.<br /> <b>Results: </b>The authors found that the following situations could provoke deterioration in the health of combatants due to fear: contact with a patient with COVID-19, planned posting to the hotbed of COVID-19, military service in the area of high risk of contact with patients with COVID-19, receiving information about COVID-19, receiving false information about COVID-19, disruption of critical infrastructure due to quarantine measures.the authorshave provided an algorithm by which these traumatic situations provoke the development of health disorders. In particular, they cause fear of social and work stigmatization due to infection with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), fear of suffering or death during COVID-19, ear that family members will become infected, erroneous conclusions about someone deliberately exaggerating the dangers of COVID-19, feeling of injustice and incorrectness of the quarantine measures, household discomfort and organizational stress. These experiences change the subjective picture of the future of combatants, and this provokes the development or exacerbation of pre-existing mental and somatic disorders. The impact of information on COVID-19 on combatant health disorders was investigated.<br /> <b>Conclusions: </b>The authors believe that this knowledge will help to develop special psychoprophylactic approaches that would prevent the development of mental and somatic disorders due to the COVID-19 pandemic and improve the quality of quarantine measures. It will also allow measures to be taken to prevent a reduction in the army’s combat effectiveness through a pandemic and quarantine.

The aim: The purpose of this study was to examine the most common coping strategies in the population in quarantine settings. Materials and methods: The study used the following set of methods: a general questionnaire aimed at studying socio-demographic data, living conditions during quarantine, lifestyle during quarantine, the presence of chronic diseases and psychodiagnostic methods: assessment of distress R.Kessler, assessment of the presence of manifestations of anxiety-depressive response GAD-7, depression self-assessment scale PHQ-9, stress-overcoming behavior strategies (E. Heim), as well as mathematical methods for processing the obtained data. Results: Social and psychological characteristics of the examined were investigated, where coping strategies during the quarantine period play a role in the adaptation process and the state of the psychoemotional sphere. Non-adaptive cognitive coping was characterized by the presence of direct strong correlations with high levels of distress and high rates of anxiety and depression. Conclusions: Quarantine restrictions are risk factors for mental health deterioration. In these settings, the interaction of stress factors with anti-stress protection components is important, among which coping strategies play a leading role.