Both solid particles and column diameter affect the gas holdup and flow regimes in slurry bubble columns, but investigations of the combined effects are not to be found. This study shows the simultaneous impacts on the overall gas holdup and flow regime transitions and determines the dominant effects in slurry bubble columns on the centi‐scale containing solid particle concentrations up to 20 vol %. Additional tomography measurements are presented to visualize the gas phase flow and the spatial gas phase distribution in the column.