The emergence of resistance to antibiotics in microorganisms has been a matter of public health concern. This resistance could be caused by mutation, acquisition of extra genetic materials and indiscriminate or persistent use of antibiotics which has rendered these therapeutic agents less effective and less Potent. To overcome this therapeutic challenge several Phytochemicals have been reported to possess significant antibiotics properties that could serve at alternative therapy as against synthetic agents. This review is focused on reporting the various investigation relating to Phytochemicals as potential therapy against antibiotics resistance.