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Antimalarial principles of Spathodeu cumpunulafu stem bark extract were isolated and characterized. The antimalarial principles in the stem bark were 3P-hydroxyurs-12-en-28-oic acid (ursolic acid) and two of its derivatives; 3~hydroxyurs-12,19-dien-28-oic acid (tomentosolic acid) and 3~,2O~-dihydroxyurs-12-en-28 oic acid. This is the first report of the isolation of ursolic acid and its derivatives as antimalarial compounds.

The action of extracts of the stem bark of Spathodea campanulata on Pla.smodium berghei berghei in mice has been studied. The blood schizontocidal activity of the extracts was studied in early and established infections using chloroquine as the reference drug. The prophylactic action of the extracts was also investigated with pyrimethamine as the standard drug. The hexane and chloroform extracts of the stem bark showed blood schizontocidal action in both the 4-Day test and Rane test. The chloroform extract demonstrated some prophylactic properties while the aqueous extract did not show any significant antimalarial property. tion of the leaves, the action of the stem bark extracts of the plant was therefore investigated.

Effects of extracts of Spathodea campanulata on Plasmodium berghei berghei in mice have been investigated. Schizontocidal activity of the plant in blood was determined on both the early and established infections. The repository action of the plant was also investigated. Chloroquine and pyrimethamine were used as reference drugs. The alcoholic extract of the leaves of the plant demonstrated antiplasmodial activity. The plant extract was more effective in treating the early infection than the established one. This report provides scientific data for the use of the aqueous alcoholic decoction of the leaves of Spathodea campanulata for the treatment of malaria.

Antimalarial principles of Spathodea campanulata stem bark extract were isolated and characterized. The antimalarial principles in the stem bark were 3β‐hydroxyurs‐12‐en‐28‐oic acid (ursolic acid) and two of its derivatives; 3β‐hydroxyurs‐12,19‐dien‐28‐oic acid (tomentosolic acid) and 3β,20β‐dihydroxyurs‐12‐en‐28 oic acid. This is the first report of the isolation of ursolic acid and its derivatives as antimalarial compounds