PurposeThe purpose of this study was to examine alexithymia among restless legs syndrome (RLS) patients, compare with healthy controls, and argue the clinical inferences of this relationship. We searched for anxiety and depression and their clinical outcomes among patients and searched whether the results are similar to previous studies.Patients and methodsEighty-seven RLS patients and 88 age, gender, and educationally matched healthy controls were assessed in Bezmialem Foundation University Hospital. RLS patients and healthy controls were assessed with the Sociodemographic Data Form constructed for the present study, 20-item Toronto Alexithymia Scale (TAS-20), Beck Depression Inventory (BDI), and Beck Anxiety Scale (BAS). The patient group was also assessed with the International Restless Legs Syndrome Study Group (IRLSSG) RLS Severity Scale.ResultsRLS patients were found to have greater TAS-20, BDI, and BAS scores compared with the control group (P < 0.05). RLS severity score was positively correlated with the scores of anxiety and depression scales. However, no significant relationship was found between scores of IRLSSG RLS scale and TAS-20 total and subscale scores.ConclusionRLS patients were found to be more alexithymic than healthy controls, whereas no significant relationship was found between RLS severity and levels of alexithymia. Still, alexithymia might be a predictor for early diagnosis and may be considered in the treatment and follow-up of RLS. RLS patients have higher depression and anxiety scores than healthy individuals. Thus, depression and anxiety should be taken into consideration throughout the RLS treatment.

Objectives: Psoriasis is a chronic, inflammatory skin disease which has been linked to psychopathology. Oxidative stress and inflammation are associated with atherogenesis and neuronal stress thus, cognitive functions might be impaired in psoriasis patients. We aimed to compare psychiatric comorbidity, neurocognitive functions, oxidative stress and inflammatory cytokine levels in psoriasis patients with healthy controls, besides to evaluate the effect of oxidative stress and inflammation on comorbidity and cognitive functions in psoriasis patients. Methods: A total of 37 patients (11 male and 26 female) aged between 18 and 65 years with at least 5 years of education who applied to the Dermatology Outpatient Clinic of the study hospital between study period; diagnosed with psoriasis by physical examination and histopathological evaluation were included in the study. The control group was formed from healthy individuals working for the hospital. Sociodemographic data form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Semantic Verbal Fluency Test (K-AS), Öktem Verbal Memory Processes Test, Auditory Consonant Trigram Test and Wisconsin Card Sorting Test were performed to all participants. In addition, blood samples of participants were analysed to assess total oxidant stress (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and proinflammatory cytokines TNF-α and IL-6 levels. Results: BDI and BAI scores, TOS, OSI, TNF-α and IL-6 levels of psoriasis patients were significantly higher than controls. Besides, the cognitive domains of learning, recall and verbal fluency in psoriasis patients were shown to be impaired. The increased levels of depression and anxiety in psoriasis did not significantly affect the serum TAS, TOS and OSI levels. Increased IL-6 and TNF-α levels were not significantly related to depression in patients with psoriasis. Conclusion: Psoriasis patients have higher risk factors than healthy controls for cognitive impairment, independent of depression, inflammation and oxidative stress levels.

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ÖzTüm dünyada vardiyalı çalışmanın yükselen yaygınlığı nedeniyle vardiyalı olarak çalışan kişilerin ve ailelerinin düzensiz yaşam tarzları ve ritimlerle ilişkisi araştırılmaktadır. Vardiyalı çalışmanın fiziksel ve ruhsal sağlığa etkisi, son yıllarda çok önemli bir araştırma alanıdır. Vardiyalı olarak çalışanlarda tıbbi komplikasyonların başlaması ve sürekliliği, çalışma ritimleri ile sirkadiyen saat arasındaki bozulmuş senkronizasyonu içermektedir. Bu bağlamda, uyku-uyanıklık bozuklukları, gastrointestinal problemler ve kardiyovasküler hastalıkların risk artışını gösteren çalışmalar bulunmaktadır. Sirkadiyen ritim uyku bozukluğu olarak bilinen vardiyalı çalışma bozukluğunun gerçek sıklığı, ruhsal ve bedensel etkileri ve tedavisi ile ilgili çok az bilgi vardır. Vardiyalı çalışma bozukluğu, iş programıy-la ilişkili uykusuzluk ve / veya aşırı uykululuk halini içerir. Bu derlemenin amacı vardiyalı çalışmanın bedensel ve ruhsal etkilerinden bahsederek vardiyalı çalışma tipi uyku bozukluğunun kliniği ve tedavi yöntemleri hakkında bilgi sunmaktır.Anahtar sözcükler: Vardiyalı çalışma, sirkadiyen ritim, uykusuzluk, aşırı uyku. AbstractWith the growing prevalence of shift work all over the the world, the relationship between the daily lives of irregular lifestyles and rhythms is being investigated for those working as shift workers and their families. The effect of shift work on physical and mental health is a very important field of research in recent years. The onset and persistence of medical complications in shift workers includes impaired synchronization between work schedule rhythms and circadian clock. In this context, studies have been carried out showing the increased risk of sleep-wake disorders, gastrointestinal problems, and cardiovascular diseases. There is little information about the actual frequency, effect on health and treatment of shift work disorder, known as circadian rhythm sleep disorder. Shift work disorder includes insomnia and/or excessive sleepiness related with the work schedule. The aim of this rewiev, mentioning about the physical and mental effects of shift work, and to provide information about the diagnosis, clinic and treatment methods of shift-work disorder.

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