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Female and diabetic patients are at higher risk for sternal SSI and should be followed up carefully after cardiac surgery to prevent the development of sternal SSI. Reducing the duration of surgery could reduce the rate of postoperative sternal SSI. The operating theater environment may have an important role in the pathogenesis of sternal SSI, and appropriate ventilation of the operating theaters would be critical in the prevention of sternal SSI.

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Major depressive disorder (MDD) is the leading cause of disability worldwide. [1] This disease is characterized by loss of interest in daily activities, sadness, and feelings of tiredness, guilt or low self-worth. Since these symptoms disturb sleep, appetite and concentration skills of individuals, depression can be defined as a debilitating disor-der by its growing direct and indirect financial burden on health care spending. The estimated lifetime prevalence varies across the cultures from 3% to 16.9%. [2] Currently, there are more than twenty different antidepressant medications targeting the monoamine systems. These drugs generally work by increasing the amount of serotonin or norepinephrine in the brain. While effective in most patients, sustained remission is