PURPOSEThe purpose of this clinical study was to evaluate the frequency and type of prosthetic complications in relation to type and properties of removable dentures and to investigate the influence of these complications and several data about the existing dentures on patient satisfaction.MATERIALS AND METHODSNinety nine patients (44 males and 55 females) wearing removable dentures have been included in the study. The complications of the patients were recorded; patient satisfaction was determined with a Visual Analog Scale (VAS) and the relationship of complications and patient satisfaction with several data about the dentures such as denture age, type of denture, centric relation and vertical dimension was investigated. Kruskal Wallis, Mann Whitney U and Chi square tests were used for statistical analyses. The results were evaluated statistically at a significance level of P<.05.RESULTSNeed for addition of artificial teeth for dentures with correct centric relations was found to be significantly lower than dentures with wrong centric relations (P<.01). Loss of retention, ulcerations and high vertical dimension affected the VAS chewing ability scores negatively and ulcerations affected the VAS phonation scores negatively (P<.05).CONCLUSIONConsidering the results of this study, it can be concluded that loss of retention, ulcerations and high vertical dimension caused patient dissatisfaction. Additionally, dentures with wrong centric relations caused need for addition of artificial teeth.

The aim of this clinical trial was to assess satisfaction, as well as the frequency and type of prosthetic complications in terms of several variables, in patients with complete dentures that had been supplied at private clinics. The study subjects were 64 patients with a mean age of 63.48 years wearing complete dentures provided at private clinics, and requesting new ones. The degree of patient satisfaction with their dentures was assessed, as well as complications and parameters related to the dentures such as the accuracy of vertical dimensions and centric relation, arrangement and possible malposition of the artificial teeth, and the border length of the denture bases. The most common complication was loss of retention (85.9%), followed by ulceration (44.2%). Mandibular dentures with long vestibular borders showed a significantly higher incidence of epulis fissuratum (P = 0.017), and denture-related sore spots influenced patients' speech ability (P = 0.023). Routine recalls seem to be important for wearers of complete dentures, as several insidious complications may develop and cause damage to the dentures as well as the patients' oral tissues. (J Oral Sci 55, 29-37, 2013)

Bu araştırmanın amacı, yaratıcı yazma, iş birlikli yaratıcı yazma ve Türkçe Öğretim Programı'nda yer alan yazma çalışmalarının, öğrencilerin yazılı anlatım becerileri ile yazmaya ilişkin tutumlarına etkisini belirlemektir. Araştırmada ön test-son test kontrol gruplu deneysel desen kullanılmıştır. Araştırmanın uygulama sürecinde, deney 1 grubunda iş birlikli yaratıcı yazma ve deney 2 grubunda yaratıcı yazma uygulamaları gerçekleştirilmiştir. Kontrol grubunda ise Türkçe Öğretim Programı'na göre yazma çalışmaları yapılmıştır. Deney ve kontrol gruplarındaki öğrencilerin, uygulamaların başında ve sonunda yazılı anlatım becerileri ile yazmaya ilişkin tutumları, ilgili ölçme araçları kullanılarak belirlenmiştir. Araştırma sonunda, deney ve kontrol gruplarındaki öğrencilerin yazılı anlatım becerileri ile yazmaya ilişkin tutum erişileri arasında deney grupları lehine istatistiksel olarak anlamlı bir fark olduğu belirlenmiştir. Deney 1 ve deney 2 gruplarındaki öğrencilerin yazılı anlatım becerileri ile yazmaya ilişkin tutum erişileri arasında ise deney 1 grubu lehine istatistiksel olarak anlamlı bir fark olduğu sonucuna ulaşılmıştır. Anahtar sözcükler: Yaratıcı yazma, iş birlikli yaratıcı yazma, yazılı anlatım, yazmaya ilişkin tutum

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Background: Ovarian cancer is the second most common gynecologic cancer with high mortality rate and generally diagnosed in advanced stages. The 5-year disease-free survival is below 40%. MicroRNAs, subset of the non-coding RNA molecules, regulate the translation in post transcriptional level by binding to specific mRNAs to promote or degrade the target oncogenes or tumor suppressor genes. Abnormal expression of miRNAs were found in numerous human cancer, including ovarian cancer. Investigating the miRNAs derived from the peripheral blood samples can be used as a marker in the diagnose, treatment and prognosis of ovarian cancer. We aimed to find biological markers for early diagnosis of ovarian cancer by investigating BRCA1 gene mutation carrier monozygotic discordant twins and their high risk healthy family individual's miRNAs. Methods: The study was conducted on monozygotic twins discordant for ovarian cancer, and the liquid biopsy exploration of miRNAs was performed on mononuclear cells that were isolated from the peripheral blood samples. The miRNA expression profile changes in the study were found by using microarray analysis. miRNA isolation procedure performed from the lymphocyte in accordance with the kit protocol. The presence and quality of the isolated miRNAs screened by electrophoresis. Raw data logarithmic analysis was studied by identifying the threshold, normalization, correlation, mean and median values. Target proteins were detected for each miRNA by using different algorithms. Results: After the comparison of monozygotic discordant twins for epithelial ovarian carcinoma upregulation of the 4 miRNAs, miR-6131, miR-1305, miR-197-3p, miR-3651 and downregulation of 4 miRNAs, miR-3135b, miR-4430, miR-664b-5p, miR-766-3p were found statically significant.