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Hirayama disease (HD) is a rare benign lower motor neuron disorder in the young with a male preponderance and usually affecting one upper extremity. It is characterized by the insidious onset and progressive weakness and wasting of a distal extremity. Generally, this disease is considered as a benign and nonprogressive motor neuron disease that stabilizes within five years of onset. We describe a 20-year-old male patient who experienced left distal upper extremity amyotrophy with no sensorial abnormality.

Leptomeningeal carcinomatosis is a rare, devastating, and mostly late-stage complication of various solid tumors and hematologic malignancies. The diagnosis can be challenging especially if malignancy is not in active phase or treatment was discontinued. A literature search revealed various unusual presentations of leptomeningeal carcinomatosis including cauda equina syndrome, radiculopathies, acute inflammatory demyelinating polyradiculoneuropathy, and others. To the best of our knowledge, this is the first case of leptomeningeal carcinomatosis presenting with acute motor axonal neuropathy variant of Guillain-Barré Syndrome and unusual cerebrospinal fluid findings known as Froin’s syndrome.

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