Objectives: Parenteral iron is used for patients who are either unable to absorb oral iron or who have increasing anemia despite adequate doses of per oral iron. Parenteral iron preparations are clearly effective, but concerns have been raised regarding adverse events and potentially long-term toxicity. So, in this study we aimed to investigate the effect of intravenous iron therapy on acute antioxidant capacity. Materials and methods:Totally 36 patients with iron deficiency anemia and 20 healthy controls were included in the study. Prior to iron infusion to subjects, blood samples were obtained for measurement of total antioxidant capacity. Then patients received 100 mg intravenous iron sucrose in an hour. And at the first hour after the infusion was completed, the blood samples were repeated.Results: Before the treatment total antioxidant capacity was significantly lower in anemic patients (280±34 μmol/L) than in control group (365±58 μmol/L) (p=0.001). Significantly decreased total antioxidant capacity (264±35 μmol/L) was found after the iron treatment (p=0.01). No adverse events related to intravenous iron were observed. Conclusion:In this study, we observed that intravenously administered iron sucrose in 100 mg dose and also iron deficiency anemia itself, caused increased oxidative stress.

Type I diabetes mellitus (TIDM) is an oxidative stress condition in addition to being a chronic metabolic disease. In this study, our aim is to investigate the activity of antioxidative enzymes and the products of oxidative stress in children and adolescents with TIDM and compare the findings with those in healthy control subjects. Materials and Methods: The study enrolled 41 children and adolescents with TIDM (mean age 11.4±3.3 years; 21 female, 20 male) and 25 healthy subjects (mean age 11.3±3.1 years; 8 female, 17 male) with a similar age and gender distribution. Serum samples were obtained to detect the antioxidative enzymes of paraoxonase (PON), arylesterase (ARE), oxidation degradation products of malondialdehyde (MDA) and also zinc which acts as an antioxidant. Results: We found a significant decrease in PON activity and zinc levels in diabetics compared to the healthy controls (p=0.021; p<0.001, respectively). Zinc was negatively correlated to hemoglobin A1c (r=-0.317, p=0.049). MDA and ARE did not show a significant difference in the TIDM patients compared to the healthy subjects. Conclusion: Zinc level and PON activity were lower in diabetic children and adolescents. Further studies with larger samples are required to confirm their roles in the following and prognosis of TIDM.