Previous detections of individual astrophysical sources of neutrinos are limited to the Sun and the supernova 1987A, whereas the origins of the diffuse flux of high-energy cosmic neutrinos remain unidentified. On 22 September 2017, we detected a high-energy neutrino, IceCube-170922A, with an energy of ~290 tera-electron volts. Its arrival direction was consistent with the location of a known γ-ray blazar, TXS 0506+056, observed to be in a flaring state. An extensive multiwavelength campaign followed, ranging from radio frequencies to γ-rays. These observations characterize the variability and energetics of the blazar and include the detection of TXS 0506+056 in very-high-energy γ-rays. This observation of a neutrino in spatial coincidence with a γ-ray-emitting blazar during an active phase suggests that blazars may be a source of high-energy neutrinos.

Detection of the IceCube-170922A neutrino coincident with the flaring blazar TXS 0506+056, the first and only ∼3σ high-energy neutrino source association to date, offers a potential breakthrough in our understanding of highenergy cosmic particles and blazar physics. We present a comprehensive analysis of TXS 0506+056 during its flaring state, using newly collected Swift, NuSTAR, and X-shooter data with Fermi observations and numerical models to constrain the blazar's particle acceleration processes and multimessenger (electromagnetic and high-energy neutrino) emissions. Accounting properly for electromagnetic cascades in the emission region, we find a physically-consistent picture only within a hybrid leptonic scenario, with γ-rays produced by external inverse-Compton processes and highenergy neutrinos via a radiatively-subdominant hadronic component. We derive robust constraints on the blazar's neutrino and cosmic-ray emissions and demonstrate that, because of cascade effects, the 0.1-100 keV emissions of TXS 0506+056 serve as a better probe of its hadronic acceleration and high-energy neutrino production processes than its GeV-TeV emissions. If the IceCube neutrino association holds, physical conditions in the TXS 0506+056 jet must be close to optimal for high-energy neutrino production, and are not favorable for ultra-high-energy cosmic-ray acceleration. Alternatively, the challenges we identify in generating a significant rate of IceCube neutrino detections from TXS 0506+056 may disfavor single-zone models, in which γ-rays and high-energy neutrinos are produced in a single emission region. In concert with continued operations of the high-energy neutrino observatories, we advocate regular X-ray monitoring of TXS 0506+056 and other blazars in order to test single-zone blazar emission models, clarify the nature and extent of their hadronic acceleration processes, and carry out the most sensitive possible search for additional multimessenger sources.

Abstract. Since GRBs fade rapidly, it is important to publish accurate, precise positions at early times. For Swift-detected bursts, the best promptly available position is most commonly the X-ray Telescope (XRT) position. We present two processes, developed by the Swift team at Leicester, which are now routinely used to improve the precision and accuracy of the XRT positions reported by the Swift team. Both methods, which are fully automated, make use of a PSF-fitting approach which accounts for the bad columns on the CCD. The first method yields positions with 90% error radii <4.4" 90% of the time, within 10-20 minutes of the trigger. The second method astrometrically corrects the position using UVOT field stars and the known mapping between the XRT and UVOT detectors, yielding enhanced positions with 90% error radii of <2.8" 90% of the time, usually 2 hours after the trigger.

Abstract. Based on light curves from the Swift Burst Analyser, we investigate whether a 'dip' feature commonly seen in the early-time hardness ratios of Swift-XRT data could arise from the juxtaposition of the decaying prompt emission and rising afterglow. We are able to model the dip as such a feature, assuming the afterglow rises as predicted by Sari and Piran [1]. Using this model we measure the initial bulk Lorentz factor of the fireball. For a sample of 23 GRBs we find a median value of Γ 0 = 225, assuming a constant-density circumburst medium; or Γ 0 = 93 if we assume a wind-like medium.

An acyl radical cyclization to form the bicyclic core of (-)-kumausallene (1) was the key feature in the 14-step, enantioselective synthesis. This work demonstrates that the bromoallene unit is robust enough to withstand multiple synthetic operations and provides the unambiguous assignment of the absolute configuration of the bromoallene.