The paper describes 6 cases of the rare disease - primary and secondary hypophysitis detected by a morphological examination of the material of endoscopic transsphenoidal resection of pituitary neoplasms. It also provides clinical and morphological comparisons and analyzes the data available in the literature.

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The results of evaluating the breeding value of rams of different genotypes by a wide range of productivity indicators of their descendants are presented. Tribal rams of the Kharkov interbreed type of Prekos breed of 2-3 years of age, as well as crosses from the introductory crossing of Prekos sheep with the Romanov breed and Merinolandsheep, were evaluated. The resulting offspring were grown under the conditions of one production flock. The evaluation considered the indicators of the reproductive ability of ewes, sex and type of birth of the offspring, the safety of lambs from birth to 20 days of age, the dynamics of the average daily growth of daughters in the uterus and at the age of birth to 20 days and from 21 to 90 days, live weight indicators were considered, cutting and length of hair of daughters at the age of 14 months. Studies have established that the average yield of lambs throughout the sample was 115.3 % per 100 ewes, with significant differences between the estimated producers - from 105.1 to 131.3 %. This indicator did not have a definite relationship with the genotype of the estimated sheep. Among the offspring of all rams, males slightly prevail over females in the ratio of 1.09 to 1. This advantage is due to the large number of rams born among same-sex twins. Their part exceeded 28 %, while only 23.4 % turned out to be similar in type of birth. By the sum of the ranks that were put to individual sheep for the indicators of the average daily growth of daughters at different periods of their growth, the best cross-breed sheep No. 1625 and No. 9953 are distinguished. On the whole, there is a fairly clear tendency for a positive relationship between the ranks for the growth rate in the embryonic period and the same indicator for posterity aged 21-90 days. According to both the ranking and the probity-based evaluation results, ram No. 1625 (a created line based on crossing with the Romanov breed) is assigned to complex improvers. The rest topping ram out to be improvers of individual traits, and the producer of the breed Prekos No. 1823 was an improvement in production of wool and length of staple. Ram No. 1960 turned out to be a complex deteriorator in the quality of offspring. The descendants of rams No. 4464 and 9953, derived from the breed of Merino landscape, reliably (p≤0.01), by 18.6-20.8 % in terms of wool coefficients, are inferior to the daughters of ram No. 1823, breed Prekos, which is an unconditional evidence of the strengthening of their characters meat productivity over wool one.

Persistent and recurrent hypercortisolism after transsphenoidal endoscopic surgery (TSS) is considered to be an urgent issue prompting the search for Cushing’s disease (CD) remission predictors. The goal was to find a combination of predictors that can forecast the remission of CD after TSS. A total of 101 patients with CD who had undergone TSS were included. One year after surgery, CD remission status was evaluated. Preoperative pituitary magnetic resonance imaging (MRI) data, preoperative results of a high-dose dexamethasone suppression test (HDDST) and morning serum cortisol level collected 24 h after TSS (24 h MSeC) were compared in patients with and without remission of hypercortisolism. Remission one year after TSS was confirmed in 63 patients. CD remission predictors one year after TSS were: adenoma size ≥ 3 mm in the absence of invasive growth and the suppression of serum cortisol ≥ 74% in the HDDST, 24 h MSeC ≤ 388 nmol/L. A total of 38 patients had three favorable values of detected predictors; all of them had CD remission one year after TSS. With long-term follow-up, 36 of them remained in remission. Patients who had no one favorable predictor had no remission of hypercortisolism one year after TSS. Our data confirmed the prospects of using a combination of selected predictors to forecast CD remission after TSS.

Fibrous hamartoma of infancy (FHI) is a rare tumor, accounting for less than 2% of soft tissue tumors occurring in the first year of life. The tumor arises from the subcutaneous tissue and is most often found in the armpit, then in the shoulder, groin and chest wall. The characteristic microscopic appearance of FHI is the presence of three tissue types in varying proportions: well-defined bundles of dense fibrous connective tissue, primitive mesenchyme (organized in nests, concentric whorls, or bands), and intermediate mature adipose tissue. Surgical removal is the main choice of treatment for this pathology. We report 2 cases of rare FHI localized in the gluteal region and the region of the posterior upper third of the thigh. At the same time, in one observation, the lesion affected only the subcutaneous fat, and in the second, a widespread invasive process in the muscles was noted. Despite the benign nature of the tumor, its spread is characterized by invasive growth (it does not have a capsule and a clear border with the surrounding tissues), which can cause difficulties for surgeons during the primary operation in determining the boundaries of FHI removal. For this purpose, we consider it expedient to use an express biopsy during surgery.