Bovine anaplasmosis, caused by Anaplasma marginale, is an infectious but non-contagious disease. It is spread through tick bites or by the mechanical transfer of fresh blood from infected to susceptible cattle from biting flies or by blood-contaminated fomites including needles, ear tagging, dehorning and castration equipment. Transplacental transmission of A. marginale may contribute to the epidemiology of bovine anaplasmosis in some regions. Bovine anaplasmosis occurs in tropical and subtropical regions worldwide. Cattle of all ages are susceptible to infection with A. marginale, but the severity of disease increases with age. Once cattle of any age become infected with A. marginale, they remain persistently infected carriers for life. Diagnosis of bovine anaplasmosis can be made by demonstration of A. marginale on stained blood smears from clinically infected animals during the acute phase of the disease, but it is not reliable for detecting infection in pre-symptomatic or carrier animals. In these instances, the infection is generally diagnosed by serologic demonstration of antibodies with confirmation by molecular detection methods. The susceptibility of wild ruminants to infection by A. marginale and the role of wild ruminants in the epidemiology of bovine anaplasmosis are incompletely known owing to lack of published research, lack of validation of diagnostic tests for these species and cross-reaction of Anaplasma spp. antibodies in serologic tests. Control measures for bovine anaplasmosis vary with geographical location and include maintenance of Anaplasma-free herds, vector control, administration of antibiotics and vaccination.

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(to be submitted to Zeit. Phys. C} for muons, and ~ 40% for electrons.level, on any new source of lepton pairs is ~ 20% of the hadronic decay contribution of the major hadronic sources is set by the data. The upper limit, at 90% confidence decays, and there is no need to invoke any "unconventional" source. The normalisation the low-mass spectrum can be explained satisfactorily by lepton pairs from hadronic p-Be collisions at 450 GeV/ c at the CERN SPS. For both electron and muon pairsWe report on the production of low-mass electron pairs and muon pa.irs in Area. An overview of the apparatus is shown in Figure la. The main components are OCR OutputThe HELIOS spectrometer is situated in the H8 beam line of the CERN SPS North 2.2 Apparatus reliably and stably throughout the experiment.The intensity was ~ 106 per burst. The targeting of the beam on to the wire worked 0.1%), a transverse diameter less than 50 pm and divergence ~ 0.2 mrad at the target.eriment to match the wire target. This beam has excellent momentum resolution (6p/ p A special 450 GeV/ c proton f'micro"-bea.m was developed for the HELIOS exp from the decay of hadrons produced in the interaction.of only 125 pm diameter, in order to minimize the radiation length traversed by photons the design. Accordingly, we have used a 4 cm long (10% interaction length) Be wire target experiment, and so the suppression of e'*'c" pairs from conversions was a key feature ofThe study of low-mass lepton pairs was one of the prime motivations of the HELIOS analysis is presented in section 4, and in section 5 results are summarised and conclusions ing, and data-taking, followed by the event reconstruction and selection in section 3. TheThe plan of this paper is as follows. In section 2 we describe the apparatus, trigger any "unconventional" source. Upper limits on any new source are presented.can be accounted for by lepton pairs from the decay of hadrons, and there is no need forThe main result is that low-mass lepton pairs, produced centrally at `/E 2 29 GeV, a measurement of the total charged multiplicity of the event.electron identincation by both transition radiation and calorimetry; a double measurement of the momentum (or energy) of both muons and electrons;Other noteworthy points are:of certain Dalitz decay modes;the measurement of photons as well as charged leptons, affording direct measurement the detector, producing two essentially independent measurements of lepton pairs; the analysis of both electron pairs and muon pairs, emphasising different aspects of from conventional sources. The most important features of the experimental approach are:Be collisions (\/Z cx 29 GeV) in the central rapidity region, is compared to the expectationIn this paper the production of electron and muon pairs, produced in 450 GeV/ c p their production level in ordinary hadronic collisions.plasma formation in relativistic heavy-ion collisions [3]: it is essential then to understand process Furthermore, lepton pairs have been suggested as a signature for quark-gluon implied by conven...

Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a chronic disease typical of cattle. Nonetheless, it can affect many mammals including humans, making it one of the most widespread zoonotic diseases worldwide. In industrialized countries, the main pathways of introduction of bTB into a herd are animal trade and contact with infected wildlife. In addition, for slow-spreading diseases with a long latent period such as bTB, shared seasonal pastures might be a between-herd transmission pathway, indeed farmers might unknowingly send infected animals to the pasture, since clinical signs are rarely evident in early infection. In this study, we developed a dynamic stochastic model to represent the spread of bTB in pastures. This was tailored to Canadian cow-calf herds, as we calibrated the model with data sourced from a recent bTB outbreak in Western Canada. We built a model for a herd with seasonal management, characterized by its partition into a group staying in the main facility and the remaining group(s) moving to summer pastures. We used this model to estimate the time of first introduction of bTB into the herd. Further, we expanded the model to include herds categorized as high-risk contacts with the index herd, in order to estimate the potential for disease spread on shared pastures. Finally, we explored two control scenarios to be applied to high-risk farms after the outbreak detection. Our results showed that the first introduction likely happened three to five years prior to the detection of the index herd, and the probability of bTB spreading in pastures was low, but not negligible. Nevertheless, the surveillance system currently in place was effective to detect potential outbreaks.

Results suggest that the M. haemolytica and P. multocida vaccine, given twice 2 weeks apart, was effective in increasing titers of antibodies against M. haemolytica in young dairy calves but did not improve calf performance or health.