Cutaneous tuberculosis incidence was recorded as 0.15%. Of the 42 patients, 23 had scrofuloderma, 17 lupus vulgaris, and 2 tuberculosis verrucosa cutis. Both men and women were affected by the disease in the second and third decades. Its duration was variable. An affirmative family history was elicited in five scrofuloderma patients. The clinical expression largely conformed to the ritual text. Variation in Mantoux test positivity was unremarkable. The disparity in the demonstration of bacilli in the smear and tissue sections was, however, quite apparent in scrofuloderma. The correlation of different parameters indicates a continuous spectrum, formed at one end by lupus vulgaris, and at another by scrofuloderma. A moderate to strongly positive Mantoux text, enormous lymphocytes in the granuloma, absence of tubercle bacilli, negative culture, and an apparently normal immunoprofile were features of lupus vulgaris; whereas scrofuloderma had a moderately positive Mantoux test, lesser number of lymphocytes in the granuloma, large number of bacilli in tissue smear and/or tissue section, raised levels of immunoglobulins, and a grossly lowered C3 levels. The other variants probably occupy a position in between.

Histo-morphological changes of the coronary vessels in cases of rheumatic heart disease (RHD) have been studied in 60 cases. Involvement of intramyocardial branches of coronary vessels in the form of active rheumatic vasculitis or inactive lesions characterized by medial hypertrophy and replacement fibrosis was seen in 15 of 60 cases. These lesions may affect myocardial function. Atherosclerosis of the pulmonary trunk and its branches was frequently seen in these hearts, indicating that this may be an important index of pulmonary hypertension. An unusual association of bicuspid aortic stenosis and RHD was seen in one case. Another case showed acute myocardial infarction due to coronary embolism from bacterial vegetation of bacterial endocarditis. Additional Indexing Words: RHD Associated lesions Coronary vessel involvement Pulmonary atherosclerosis ORONARY vessel involvement in rheumatic heart disease (RHD) is well known. The involvement can be due to the presence of paravascular bodies, which while healing, may extend into the adventitia of the vessel, or due to rheumatic vasculitis involving the vessel wall with formation of Aschoff bodies in the wall of the vessel. Myocardial changes seen in the form of myovacuolation and replacement fibrosis in the myocardium can be due to coronary vascular involvement or due to a hemodynamic effect. In this communication, the nature and the extent of coronary vessel involvement in RHD as seen on autopsy is described. The finding of rare abnormalities such

Histological appearances of the tissue fragments obtained by cavitron ultrasonic surgical aspirator (CUSA) were studied in 25 cases to determine whether the aspirated tissue could be used for diagnosis. It was found that a definite diagnosis could be made on the tissue removed by this method.

SUMMARY The role of histopathology in the diagnosis of donovanosis was assessed in 42 patients. There was heavy infiltration of the dermis with plasma and mononuclear cells but with few lymphocytes and neutrophils. The epidermis contained focal collections of polymorphoneuclear leucocytes. Endothelial proliferation and dilatation of dermal blood vessels was striking. Intracellular and extracellular Donovan bodies were shown in Giemsa stained sections from 40 patients. Pseudoepitheliomatous hyperplasia was found in biopsy specimens from a few patients. Introduction#W,