OBJECTIVETo define the type of orgasmic dysfunction in men after radical prostatectomy (RP), as absence of orgasm and orgasmic pain are recognized complaints, and changes in orgasm may lead to significant sexual dissatisfaction. PATIENTS AND METHODSUsing an unvalidated questionnaire, demographic, erectile function and orgasmic function questions were answered by 239 patients who had previously undergone a retropubic RP. RESULTSOf the 239 patients, 22% had no change in orgasm intensity, 37% reported a complete absence of orgasm, 37% had decreased orgasm intensity and 4% reported a more intense orgasm after RP than before. Pain during orgasm (dysorgasmia) occurred in 14% of the patients; in these respondents the pain reportedly occurred always (with every orgasm) in 33%, frequently in 13%, occasionally in 35%, and rarely in 19%. Most patients (55%) had orgasm-associated pain for < 1 min. CONCLUSIONSThese results indicate that orgasmic functional changes are relatively common after RP and are worth considering by clinicians and researchers.

Six Holstein cows in a commercial herd (three superovulated and three controls) and eight Holstein cows superovulated a total of 12 times in an experimental herd were studied. Superovulation was induced primarily by treatment with follicle stimulating hormone and prostaglandin F2 alpha. Milk was weighed twice daily for 30 days following treatment in the commercial herd with no effect on production. Milk samples were saved on Monday, Wednesday, and Friday to determine progesterone content. Last milk at mid-cycle averaged 8.2 ng/ml of progesterone for the cows in the experimental herd, and 7 days after superovulation they averaged 52.6 +/- 10.2 ng/ml (mean +/- standard error) of progesterone. The correlation with number of embryos recovered was .86. Therefore, milk progesterone may be useful in monitoring superovulatory response. Also, injection of prostaglandin F2 alpha into superovulated cows 9 days after a previous injection did not initiate a new estrous cycle, a fact accurately monitored by milk progesterone determinations.

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