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Surveys (NHANES) from 2005 to 2016. The prevalence of CVD among smokers was ascertained from the prevalence of four constituent conditions -congestive heart failure, coronary heart disease, angina pectoris, and heart attack. The predictors of CVD among smokers were investigated using multivariate survey logistic regression models. Results: 7,063 participants with mean age of 42.8 years who were current smokers and responded to the CVD questionnaire were considered in this analysis. The prevalence of CVD increased from 6.0% to 9.6% through the period from 2005 to 2016. Most significant increase in prevalence was seen in patients with respiratory diseases (from 10.8% to 19.2%), in obese patients (from 9.8% to 12.5%), and in binge drinkers (from 3.1% to 6.3%). The prevalence of CVD has also increased in the population with higher income (from 3.4% to 6.7%), and other than non-Hispanic whites (from 6.2% to 10.9%). The likelihood of CVD was higher among the elderly ($60years) (OR=5.07, CI=3.81-6.76), males (OR=1.35, CI=1.04-1.76), and respondents with ,400%-FPL (OR=1.84, CI=1.18-2.88). The likelihood of CVD was also higher among patients ailing with respiratory diseases (OR=3.39, CI=2.70-4.27), with diabetes (OR=2.84, CI=2.11-3.81), and with obesity (OR=1.54, CI=1.23-1.94). The proportion of patients suffering with one CVD disorder only who used a CV drug rose from 73% to 83% over the study period. Conclusions: The increase in prevalence of CVD among, both at an overall level and in certain subpopulations will be of concern to policy makers and clinical practitioners alike.