We propose a role for Th17 and Th2 T cells in chronic inflammation in lungs of patients with CF. High concentrations of these cytokines/chemokines in CF airways precede infection with P. aeruginosa.

A lack of correlation between systemic and local IgE production at mucosal sites has been reported for allergic asthma [1–5], allergic rhinitis [6, 7] and chronic rhinosinusitis with nasal polyps [8–10]. In allergic asthmatics, local IgE production is higher than in nonallergic asthmatics [3] and high local IgE levels have been linked to the clinical phenotype. Interestingly, in cases of nasal polyps, local IgE targets mainly superantigens [8].

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Table of contentsA1 Role of fibrocytes in allergic rhinitisMarie-Ève Côté, Marie-Ève Boulay, Sophie Plante, Jamila Chakir, Louis-Philippe BouletA2 Patterns of aeroallergens sensitization in Northern AlbertaHanan Ahmed, Maria-Beatriz Ospina, Kyriaki Sideri, Harissios VliagoftisA3 Addressing acceptable risk for adolescents with Food-Induced Anaphylaxis (FIA)Sara F. Johnson, Roberta L. WoodgateA4 Outcomes of matched related and unrelated bone marrow transplantation after reduced-toxicity conditioning for children suffering from Chronic Granulomatous DiseaseGuilhem Cros, Pierre Teira, Sonia Cellot, Henrique Bittencourt, Helene Decaluwe, Marie France Vachon, Michel Duval, Elie HaddadA5 Outcomes of patients with severe combined immunodeficiency (SCID) prior to and after initiation of newborn screening for SCID in OntarioVy H.D. Kim, Anne Pham-Huy, Eyal GrunebaumA6 Detection of regulatory B cells in the airways of subjects with asthmaJohn-Paul Oliveria, Stephanie Phan, Mark W. Tenn, Damian Tworek, Steven G. Smith, Adrian J. Baatjes, Caitlin D. Obminski, Caroline E. Munoz, Tara X. Scime, Roma Sehmi, Gail M GauvreauA7 Characterization of IgE-expressing B cells in the airways and peripheral blood of allergic asthmatic subjectsJohn-Paul Oliveria, Stephanie Phan, Mark W. Tenn, Brittany M Salter, Steven G Smith, Caitlin D Obminski, Caroline E Munoz, Abbey Schlatman, Tara X Scime, Rick Watson, Roma Sehmi, Gail M GauvreauA8 Pregnancy: could it be a risk factor for primary immunodeficient patientsRoya Sherkat, Razieh Khoshnevisan, Saba SheikhbahaeiA9 Clinical experience with Octagam: a Canadian retrospective chart reviewStephen Betschel, Richard Warrington, Robert SchellenbergA10 Kounis syndrome secondary to contrast media with inferior ST elevations and bilateral ischemic strokeMichael N Fein, Jean-Philippe PelletierA11 Honey bee venom immunotherapy ineffective in bumble bee-induced anaphylaxis: case report and review of literatureManstein Kan, Robert SchellenbergA12 Delayed immune reconstitution occurring after multiple immune complications of hematological stem cell transplantation for a leaky SCIDRoxane Labrosse, Guilhem Cros, Pierre Teira, Henrique Bittencourt, Helene Decaluwe, Michel Duval, Elie HaddadA13 Comparison of Three Case Reports of Acquired Angioedema: presentation, management and outcomeRaymond Mak, James Loh, Amin KananiA14 Sitagliptin-associated angioedema not related to concurrent use of ARB or ACE inhibitorDominik A. Nowak, Paul K. KeithA15 Sneddon-Wilkinson subcorneal pustular dermatosis associated with an IgA monoclonal gammopathyDaniel Pannozzo, Dominik A. Nowak, Hermenio C. LimaA16 Omalizumab can be effective in patients with allergic bronchopulmonary aspergillosisDiana Pham, Hoang Pham, Gonzalo G. Alvarez, Istvan T. Bencze, Krishna B. Sharma, Mark Smith, Shawn Aaron, Jennifer Block, Tara Keays, Judith Leech, David Schneidermen, Jodi Cameron, Jennifer Forgie, Alicia Ring, John W. O’Quinn, Stephanie Santucci, William H. YangA17 Efficacious use of omalizumab in the treatment of cystic fibrosisDiana Pham, Ho...