This study was undertaken to investigate whether chronic immobilization stress interferes with lead-induced reproductive toxicity in rats. Early pubertal male Wistar rats were subjected to either restraint stress (5 hr/day) or maintained on lead (0.15%) containing water or both for 60 days. Restraint stress or lead treatment significantly decreased the weight of the testes and epididymis. The daily sperm production, epididymal sperm count, sperm motility, and sperm viability were also decreased after exposure to lead or subjected to restraint stress. The levels of serum testosterone and also activity levels of testicular hydroxysteroid dehydrogenases were significantly decreased with a significant increase in the serum follicle stimulating and luteinizing hormone levels in rats exposed to lead or restraint stress indicating decreased steroidogenesis. A significant increase in lipid peroxidation levels and decrease in catalase and superoxide dismutase activity levels were observed in the testes of rats subjected to restraint stress or exposed to lead indicating increased oxidative stress. Extensive histopathological malformations were observed in the testis of the treated rats. From the findings, the study suggests that restraint stress or exposure to lead affects male reproduction in rats by inducing oxidative stress followed by decreasing steroidogenesis and spermatogenesis. A significant decrease in spermatogenesis and steroidogenesis was also observed in rats subjected to both restraint stress and lead treatment as compared to lead alone treated rats indicating immobilization stress augments lead-induced testicular and epididymal toxicity in rats.

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Menopausal stage is marked by weight gain and abnormalglucosemetabolism leading to metabolic syndrome susceptibility. The incidence of obesity in post-menopausal women tends to increase due to lack of activity; higher dietary intake and the effect of decreased oestrogen lead to alteration in insulin sensitivity. The present study was done on the correlation between Body Mass Index (BMI) and fasting glucose in post-menopausal women. Forty-six healthy post-menopausal women were selected by purposive non-probability sampling technique. Study was conducted in a selected village, Bangalore. Body weight, height and 12 hours fasting blood glucose were measured. Data gathered were analysed and interpreted using both descriptive and inferential statistics. The study results showed a significant positive correlation between BMI and fasting glucose (r=0.300, p

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