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Acute lymphoblastic leukemia is more common in children, accounting for 85% of childhood leukemias. The incidence of this disease is highest in the three to four year old age group, falling off by ten years. L-asparaginase is an effective antineoplastic agent, used in the acute lymphoblastic leukemia chemotherapy. It has been an integral part of combination chemotherapy protocols of pediatric acute lymphoblastic leukemia for almost 3 decades. It is the first enzyme to be therapeutically effective in human malignant disease. Native or PEGylated L-asparaginase (ASNase or PEG-ASNase) are highly specific for the deamination of L-asparagine (Asn) to aspartic acid and ammonia. Depletion of Laspargine leads to a nutritional deprivation and inhibition of protein biosynthesis, resulting in apoptosis in T-lymphoblastic leukemia's, which require L-aspargine from external sources. This review article comprises detailed information about L-asparaginase historical developments of therapy, its mechanism of action, Advantages of PEG-Lasparaginase versus native preparations, Pharmacokinetic and Pharmacodynamics models of the enzyme, Clinical potential ,its efficacy and host resistance to ASNase.

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This paper proposes to design a voice and gesture controlled robotic vehicle (quad-copter) using LabVIEW. Voice commands are based on natural spoken language and gestures are used to direct the vehicle in the particular direction, so as to obtain a smoother working system between human and mobile robot, by coordinating voice and visual information. Keywords-Voice, quad copter, Lab view, visual informationFig.1. Block Diagram of VI Based Quadcopter Control 978-1-4799-6818-3/15/$31.00

In recent years there has been a phenomenal increase in the use of alkaline proteases as industrial catalysts. These enzymes offer advantages over the use of conventional chemical catalysts for numerous reasons, for example they exhibit high catalytic activity, a high degree of substrate specificity, can be produced in large amounts and are economically viable. Bacterial alkaline proteases constitute an important group of industrial enzymes. The objective of the present study was to determine the significant parameters in the economical production and optimize the conditions for alkaline protease by Bacillus subtilis MTCC1790 in submerged fermentation by using Taguchi experimental design. This approach facilitated the study of interaction of a large number of variables spanned by factors and their settings with a small number of experimental runs leading to considerable economy in time and cost for the process optimization. There are Five factors viz., carbon, nitrogen, metal ions, inoculum% and agitation, each at two levels were selected and an orthogonal array layout of L16 (4)5 performed. The experiment result indicated that dextrose (0.6%), NH 4 Cl (0.6 %), Ca 2+ as metal ions, inoculum (8%) and agitation (100 rpm) were the important factors for alkaline protease production. At this optimum condition, the yield of protease production by Bacillus subtilis MTCC1790 was found to be 286 U/mL.