The aim of our study was to enhance the bioavailability of ranolazine by using herbal-bioenhancer quercetin in rats and to study the role of P-glycoprotein (P-gp) in vitro models. In single dose study (SDS), rats were divided into four groups, Group I was treated with 0.5% sodium carboxy methyl cellulose (SCMC), Group II was treated with ranolazine (14 mg/kg), Group III was treated with quercetin (20 mg/kg) and Group IV was treated with both ranolazine and quercetin. The blood samples were collected at 0.5, 1, 2, 3, 4, 6, 8 and 12 h, and the concentration of ranolazine in the plasma was estimated by reverse phase high performance liquid chromatography (RP-HPLC) method. In multiple dose study (MDS), rats were treated with same drugs for 7 days. On 8th day, the concentration of ranolazine in plasma was estimated. In vitro study performed on the rat and chick intestinal sacs to study the intestinal transport of ranolazine in the presence and absence of quercetin and verapamil (P-gp-inhibitor). Quercetin increased the peak concentration (Cmax) of ranolazine from 254 ± 8.45 to 324 ± 10.21 and 331 ± 9.65 ng/mL in SDS and MDS, respectively. Quercetin also increased area under the curve (AUC) of ranolazine from 1565.12 ± 52.24 to 2016.98 ± 142.65 and 2070.85 ± 271.60 ng/mL/h in SDS and MDS, respectively. The transport of ranolazine from mucosal side to serosal side was increased in presence of quercetin. Quercetin is an inhibitor of CYP3A4 and P-gp. So it increased the AUC and Cmax of ranolazine.

A cross-sectional study of 250 cases of type 2 diabetes management was conducted in a governmental tertiary care hospital of urban south India to determine the comparative prevalence of type 2 diabetes and its comorbidity with cardiovascular diseases in diabetic population, core drug use indicators and drug utilization pattern in the management of diabetics entirely and with cardiovascular diseases. Highest prevalent age group for type 2 diabetes/cardiovascular diseases (greater incidence in female than male) was 51-60 years. The 62.8% prevalence of cardiovascular diseases in the diabetic population ascertained in the study could provide an evidence-based rationale for the World Health Organization guidelines for the management of hypertension in type 2 diabetics. Incidence of polypharmacy (6.06, the mean number of total drug products prescribed); 59.26% of encounters prescribed antibiotics; 17.6 and 18.5 min of average consultation and dispensing time, respectively; 100% of drugs actually dispensed and adequately labeled; 81.26% of patients having knowledge of correct dosage and average drug cost of Indian Rupees 145.54 per prescription were the core drug use indicators found mainly. Moreover, drugs prescribed from the Essential Drug List were more than 90% and thereby indicated the drug use in this set-up quite rational. Around 71.09% of cardiovascular agents prescribed by generic name revealed the cost effective medical care. Among the agents in type 2 diabetes management, Actrapid® (35.43%) was the highest. Among the cardiovascular agents prescribed, lasix (19.37%) was the highest. Cardiovascular agents prescribed orally by 76.48% signified the good prescription habit indicating the improved patients’ adherence to the treatment. The present study emphasizes the need of early detection of hypertension as a preliminary diagnostic parameter of cardiovascular diseases in diabetics and appropriate management through concomitant therapy of cardiovascular drugs to minimize the risks of death.

Aviation crashes all over the world have recently been on the high rise, stemming from negligence, mechanical faults, weather, ground control errors, pilot errors, taxing and maintenance crew errors as are probable reasons for such accidents. This case study models the probabilistic risk assessment of runway incursion data endeavored to determine the correlation in between the reported incursions that occurred at Nagpur airport between fiscal years 2005 and 2015 and the meteorological conditions, times of day, and presence of an air traffic control tower of Nagpur Airport. With runway incursions long-plaguing the safety of aviators, their passengers, and aviation refining the body of knowledge underpinning incursions coupled with ongoing prevention efforts aspire to diminish the annual incidence of incursions, increase safety, and save lives. In accordance with this mission, mining the Civil Organization (ICAO), and Federal Aviation Association (FAA) runway incursion databases and analyzing the resulting hours, and at airport with an air traffic control tower.

The aim of this study was to assess the drug utilization pattern of parenteral antibiotics in medicine units. A prospective and observational study was done on patients admitted in medicine indoor. Information regarding patient demographic details, patient medication history, and reason for admission, medication details and lab investigations. Patient drug therapy details such as diagnosis, clinical condition, therapy details such as name of the antibiotics, dose, route, frequency, duration of treatment were collected and recorded in performa. Rationality was assessed by using standard guidelines, micromedex, and NFI. Drug interactions and ADR were assessed by using standard text books like stockley drug interactions text book 8 th edition. And Micromedex. A 310 patients received parenteral antibiotics in the medicine units was found to be 12.54%. amongst incidence of use of parenteral antibiotics was highest in medicine unit B (42.12%). Cephalosporins (64.54%) were the most frequently prescribed class of parenteral antibiotics. ceftriaxone (53.63%) was the frequently used antibiotic. Cefriaxone is commonly prescribed for viral fever. 43% of major drug interactions were identified. It is essential that appropriate guidelines on the use of parenteral antibiotics are implemented to prevent irrational use of antibiotics.