BackgroundPsoriasis is a disease which may have direct impact on the psychological and social aspects, particularly due to its visibility. To date, we are unaware of any study showing relationship between psoriasis and psychological parameters such as psychological vulnerability and coping strategies.Objectiveto evaluate the effects of psoriasis on some psychological parameters in an Iranian population.MethodsPatients having histopathologically confirmed psoriasis for at least 6 months attending the Clinic of Razi Hospital and evaluated by PASI,CISS,IPQ-RResultsThere were 101 females and 99 males with the mean age of 43.2 (±16.32). The mean PASI Score was 6.58 ± 6.04. Diffuse skin involvement was the commonest form of disease (133 patients, 66.5%). the highest score for Illness perception belongs to those with genitalia involvement (185.2, worst illness perception) and the lowest score for Illness perception belong to those with nail involvement (168.2). Consistently, the lowest score of facing with the problems (CISS: approach strategy to disease) belongs to those with hand involvement (50.5) whereas the highest score belongs to those with genitalia involvement (60.4). There was significant correlation between psychological vulnerability vs. Illness perception score as well as psychological vulnerability vs. coping strategies score. Surprisingly, PASI score had insignificant relationship with illness perception, coping strategies or psychological vulnerability score.ConclusionPASI score as a representing factor of skin involvement has limited role in predicting effect of psoriasis on mental status and illness perception of psoriatic patients. Psychological vulnerability of patients is the main predicting factor of illness perception and coping strategiesThere were 101 females and 99 males with the mean age of 43.2 (±16.32). The mean PASI Score was 6.58 ± 6.04. Diffuse skin involvement was the commonest form of disease (133 patients, 66.5%). the highest score for Illness perception belongs to those with genitalia involvement (185.2, worst illness perception) and the lowest score for Illness perception belong to those with nail involvement (168.2). Consistently, the lowest score of facing with the problems (CISS: approach strategy to disease) belongs to those with hand involvement (50.5) whereas the highest score belongs to those with genitalia involvement (60.4). There was significant correlation between psychological vulnerability vs. Illness perception score as well as psychological vulnerability vs. coping strategies score. Surprisingly, PASI score had insignificant relationship with illness perception, coping strategies or psychological vulnerability score.There were 101 females and 99 males with the mean age of 43.2 (±16.32). The mean PASI Score was 6.58 ± 6.04. Diffuse skin involvement was the commonest form of disease (133 patients, 66.5%). the highest score for Illness perception belongs to those with genitalia involvement (185.2, worst illness perception) and the lowest score for Illness perception belong...

Background Pemphigus is a potentially fatal disease if left untreated. Valid scoring systems and defined cut-off values for classification of patients would help with better management through specified pharmaceutical and non-pharmaceutical treatments. Methods In this study, pemphigus patients who were receiving immunosuppressive treatments and had recent disease relapse were recruited for examination of pemphigus disease area index(PDAI), autoimmune bullous skin disorder intensity score (ABSIS), physician global assessment (PGA), autoimmune bullous disease quality of life (ABQoL), anti-desmoglein 1 (anti-Dsg1), and anti-Dsg3 autoantibody titers from December-2017 to February-2018. Cut-off values were estimated using model-based clustering classification and the 25th and 75th percentiles approach, performed separately for the exclusive cutaneous, exclusive mucosal, and mucocutaneous groups. Results In the 109 included patients, the 25th and 75th percentiles cut-offs were 6.2 and 27 for PDAI score, and 4 and 29.5 for ABSIS score. The model-based analysis resulted in two groups (cut-point:15) for PDAI score, and three groups (cut-points:6.4 and 31.5) for ABSIS score. The groups were significantly different for the PDAI, ABSIS, PGA, and ABQoL values. Based on anti-Dsg1 autoantibody values, the model-based analysis cut-point was 128 and the 25th and 75th percentiles cut-offs were 98 and 182. Anti-Dsg3 autoantibody values did not differentiate between pemphigus severity classes. Conclusions Estimated cut-off values based on the anti-Dsg1 level, PDAI, and ABSIS scoring systems could be used to classify patients into different severity grades for better management and prognosis.

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Psoriasis is a chronic inflammatory disorder, involving skin, nails, and joints. 1 This relatively common dermatosis affects both adults and children, and is characterized by circumscribed erythemato-squamous papules and plaques that may affect any body region. Psoriasis has a large impact on quality of life (QoL) due to disease symptoms such as pruritus, the physical appearance of skin lesions, and complications due to treatment such as adverse drug effects and costs of treatment. 1