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Letrozole is a third-generation aromatase inhibitor used for hormonal-sensitive breast cancer in postmenopausal women. Several analytical methods were developed to analyze Letrozole. The present review clearly covers all the analytical techniques used for the analysis of Letrozole available till date, which helps the researchers in developing new methods for estimation of Letrozole by considering the pros and cons of the previously developed methods. Figure 1: Structure of Letrozole. Letrozole (Figure 1) is chemically known as 4-[(4-cyanophenyl)-(1, 2, 4-triazol-1-yl) methyl] benzonitrile, with molecular formula C 17 H 11 N 5 and is freely soluble in dichloromethane; slightly soluble in ethanol; practically insoluble in water. It is a third-generation aromatase inhibitor used for hormonal-sensitive breast cancer in postmenopausal women. A very low daily dose of Letrozole is sufficient for unveiling antitumor activity and it is highly potent and selective and well tolerated [1]. Aromatase inhibitors can be classified based on their chemical structure as steroidal (type I inhibitors) and nonsteroidal (type II inhibitors), where anastrozole and Letrozole are nonsteroidal inhibitors and exemestane is a steroidal inhibitor [2]. Catalysis of enzyme aromatase was the final step in biosynthesis of estrogen so this step can be inhibited for inhibition of estrogen production [3].

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Tomato (Solanum lycopersicum L.) is an important vegetable crop grown worldwide after potato. Tomato has its origin in the South American Andes. Tomatoes contribute to a healthy, well-balanced diet. They are rich in minerals, vitamins, essential amino acids, sugars and dietary fibres. Tomato contains much vitamin B and C, iron and phosphorus. In India, tomato occupies an area of 808.5 thousand hectare with production of 19696.9 thousand metric tonnes and productivity of 24.4 metric tonnes per hectare (Horticulture Statistics Division, Department of Agriculture, Co-operation & Farmer's Welfare, 2016-17). Major tomato growing states in India are