whether "endogenous" or "reactive" need not concern us here-and that the disappearance of the compulsion is a direct consequence of the improvement in mood. We would need to examine a group of compulsive eaters who remained depressed after jejeunoileostomy to test this hypothesis and so far we have not found such a combination of features. Certainly, this explanation would be consistent with the conclusion that depression accompanying obesity is often consequential rather than causal.

normal English and German sUbjectsA major problem in quantitating dosage equivalence of diuretics is the variation in response between subjects in normal populations as well as in patients with edema. There are also wide variations in response within subjects. Some of this variation can be explained by measurement of factors present prior to drug administration. Known examples are the correlation between the aldosterone secretion rate before treatment and the diuretic response to ethacrynic acid,5 the correlation Supported by Hoechst Phannaceuticals, England.

Frusemide was added to the perfusate used to flush kidneys prior to transplantation. The 133Xe wash-out technique was used to measure renal blood flows before and after transplantation and the clearance curves were analysed into cortical and medullary components. It is concluded that the addition of frusemide to the perfusate contributes significantly to the restoration of a satisfactory blood flow to a transplanted kidney.

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