A new, simple, rapid, accurate and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Aspirin and Caffeine, in Active Pharmaceutical Ingredient form as well as in combined tablet dosage form. Chromatography was carried out on Symmetry ODS C18 (4.6mm × 250mm, 5µm) column using a mixture of Methanol: Acetonitrile (35:65v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 273nm. The retention time of the Aspirin and Caffeine, was 2.085, 5.262±0.02min respectively. The method produces linear responses in the concentration range of 30-70mg/ml of Aspirin and 6-14mg/ml of Caffeine. The mean % assay of marketed formulation was found to be 100.04%, and % recovery was observed in the range of 98-102%. Relative standard deviation for the precision study was found <2%. The developed method is simple, precise and rapid, making it suitable for estimation of Aspirin and Caffeinein API and combined tablet dosage form. The method is useful in the quality control of bulk and pharmaceutical formulations.