An efficient, simple one pot, two step procedure has been developed for the synthesis of 2-arylidenehydrazinyl-4-arylthiazole. The reaction of aromatic aldehyde, thiosemicarbazide and phenacyl bromide gave the desired products in good yield. The first reaction product thiosemicarbazone was obtained on reaction with aromatic aldehyde and thiosemicarbazide; without isolating this directly treated with phenacyl bromide in presence of acidic buffer at room temperature desired product was obtained with simple workup procedure.

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Mixed ligand metal complexes of azo quinoline and thiosemicarbazone with Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions were synthesized. The structure and possible geometry of all the metal(II) complexes were analyzed and supported by IR, mass spectrum, elemental analysis, TG-DTA, electronic spectra (UV), magnetic susceptibility and molar conductance. The synthesized compounds were studied for their antibacterial, antifungal and antimalarial activities. The antimicrobial activity was carried out against bacteria (two Gram-positive bacteria and two Gram-negative bacteria), three fungal strain and one malarial pathogen

Present study described the synthesis of mixed ligand metal complexes of Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II). Metal complexes were synthesized by two ligands such as 8-hydroxyquinoline derivative (primary ligand) and bis(indolyl)methane derivative (secondary ligand). The ligands and their transition metal complexes were characterized by IR, 1H NMR, mass spectrum, elemental analysis, TGA, electronic spectra (UV) and molar conductance. The results of analysis predicted that both ligands are bidentate and resulting complexes are ML1L2 type with molar ratio 1:1:1. To screen their biological potential, the antibacterial and antifungal activity of synthesized compounds have also been investigated. Results of antimicrobial activity were expressed as minimum inhibitory concentration (MIC). Synthesized complexes showed moderate to excellent antimicrobial activity against pathogens. Further, the more potent antimicrobial complexes of Fe(II) and Co(II) were docked with topoisomerase II as a receptor protein, Fe-complex bound to Met1113 (2.53 Å), Asn1296 (2.86 Å) and with nucleotide DC12 (3.28 Å). Similarly, Co-complex bound to Lys1276 (2.27 Å), Leu1280 (2.40 Å), Thr1325 (2.37 Å) and Gly1332 (2.42 Å) via intermolecular hydrogen bonding.