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Heat shock protein 70 is a molecular chaperone which expressed during oxidative stress to protect the cell from damage. Preeclampsia is a hypertensive disorder with an oxidative stress imbalance. Antioxidant defenses appear to be depleted during preeclampsia resulting in increased oxidative stress. Various alternative medicines are employed to increase the endogenous antioxidant level during preeclampsia. The aim of the present study was to determine the modulatory effect of medicinal plants, Camellia sinensis and Mentha spicata on oxidative stress, antioxidant and thiol status using placental explant as the model system. Placental explants were cultured from the placental tissues of both normotensive and preeclamptic subjects. The lipid peroxide, total antioxidant capacity, glutathione redox ratio, HSP70 levels were measured in the placental explants with and without incubation with tea, mint and mint-tea. The addition of these three extracts increased the TAC and GRR in both placental explants with decrease in the LPO level. The expression of HSP70 also decreased more significantly in preeclamptic explants on addition of tea and mint extracts due to the restoration of cell homeostasis via maintaining the antioxidant status. In view of the above results, mint-tea may emerge as an effective antioxidant, preventing cell damage during stress condition.

The possibilities of nuclear molecular configurations in symmetric and asymmetric heavy ion collisions are investigated by choosing a proper parametrization for the molecule-like compound state.We treat the nucleus as a rotating liquid drop in terms of the elliptic lemniscatoid parametrization suggested by Royer and Remaud which describes all deformed shapes that occur during the process of fusion of two nuclei, starting from two touching spheres to a single one with the intermediate formation of a deep neck. Only one parameter (s for the symmetric and s& for the conditional asymmetric case) is needed to define all the shapes encountered in the process. The shape has a neck as long as s or s, is less than 1/&2. In this parametrization, analytical expressions can be obtained for volume, surface, and moment of inertia while the Coulomb energy has to be evaluated numerically. The total energy of the system is calculated as a function of the parameter s or s&, for various spins and if the stable shape corresponding to minimum energy is one with a neck, then it is concluded that the molecular configuration is possible. Our model yields results which are in good agreement with the experimental findings.

Introduction and Aims: ultrasound had revolutionized the nerve block by, increasing the reliability with less complications. This study evaluates the block characteristics and efficacy between perivascular and perineural ultrasound guided axillary brachial plexus block for upper limb surgeries. Materials and Methods: 100 patients in the age group of 18-60 years belonging to ASA I,II physical status undergoing axillary block in upper limb surgeries were randomly allocated into Group PN-perineural (n=50) and Group PV-perivascular (n=50). In both the groups Musculocutaneous nerve block done with 6ml of local anaesthetic mixture. In perineural group, radial nerve, median nerve and the ulnar nerve were anaesthetized separately with 8ml of local anaesthetic mixture respectively. In perivascular group, the needle tip was then advanced dorsal to the artery, corresponding to 6'o clock position. 24ml of local anaesthetic mixture was incremently injected. The primary objective was to assess the success rate of blockade for surgery. The secondary objectives were to assess the onset and duration of sensory and motor block and to study the incidence of adverse effects.Results: There was no statistical significance in the success rate of blockade between the techniques (PN-98% and PV 96% with P value is 0.362).The sensory and motor onset time in PN group(6.98 min,10.22 min) is faster than PV group(10.96 min,13.50) with P value was<0.01.The mean duration of the blockade was significantly higher in the PN group. Conclusion: we conclude that the USG guided perineural technique as more reliable than the USG guided perivascular technique of axillary block.

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