BACKGROUNDBloodstream infections (BSIs) are life-threatening. Microbiological cultures take time for reporting. It is essential to start initial appropriate empirical treatment to reduce morbidity and mortality due to septicaemia. One should know the local epidemiology and susceptibility pattern of the isolates to decide appropriate empirical therapy. MATERIALS AND METHODSA retrospective analysis of data from blood cultures was done over a period of 4 years at a tertiary care teaching hospital. Trends in bacterial aetiology and susceptibility pattern was studied. ) as predominant aetiological agent followed by Coagulase negative staphylococci (29.3%) and Enterococci (26.5%). Increase in multidrug resistant pathogens was observed over the years with 60% of the isolates being MDR. The percentage of ESBL producing GNB was ranging between 60% -62%, while that of Amp C and Metallobetalactamase producers were ranging between 69% -71% and 13.5% -21% respectively. Amongst gram positive Vancomycin resistance was not seen in staphylococci, but was observed in Enterococci (2% to 5%). All gram positive cocci were 100% sensitive to Linezolid. RESULTS CONCLUSIONKnowing the local epidemiology and susceptibility of pathogens causing septicaemia is important to decide initial appropriate treatment in order to improve the clinical outcome of sepsis.

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