Guillain-Barré syndrome (GBS) is acute, ascending, immune-mediated, monophasic polyneuropathy, which manifests itself as a lower motor neuron lesion, which occurs mostly after a prior infection. It is autoimmune in origin and has an impact on the peripheral nervous system. GBS is usually not linked to an autoimmune or other systemic condition and is most frequently a post-infectious disorder that affects healthy patients. The symptoms of GBS, an acute immune-mediated polyradiculoneuropathy, include symmetrical limb weakness that worsens quickly and hypo-or areflexia. There may also be sensory complaints, involvement of cranial and autonomic nerve fibres, and frequent pain that will appear before weakening. Weakness, sensory loss, weariness, and discomfort are the most typical remaining deficiencies in an atypical variant of GBS. This case also describes the variant of atypical GBS. A 10-year-old girl was referred to the hospital with complaints of difficulty in swallowing, drooling of saliva, weakness of left upper and bilateral lower limbs, and fever for 10 days. There was no past history of travelling or infection. At the time of admission, the patient was on oxygen support for breathing and she was transferred to ICU immediately. Investigations were done such as a nerve conduction velocity test and complete blood count. Neuro-physiotherapy of the patient was started after 35 days of hospitalisation. With proper rehabilitation, the patient was able to gain strength and the ability to swallow food. The patient was able to resume her academic career.

Coronavirus disease 2019 (COVID-19) has spread around the globe. The most common symptoms associated with this are usually respiratory, but different central nervous system manifestations have been reported. There are many cases of Guillain-Barre syndrome (GBS) post-COVID-19. However, only a few simultaneous afflictions of COVID-19 with GBS have been reported. Therefore, our study aims to investigate a case of GBS along with COVID-19 infection in India. A 22-year-old male with no medical history presented with fever along with global weakness and breathing difficulty. There was no history of travel. At the time of admission, he had developed quadriparesis and had muscular strength of 2/5 in bilateral lower limbs and 3/5 in bilateral upper limbs. When the patient developed breathing difficulty, he was transferred to the intensive care unit. The cerebrospinal fluid evaluation showed albumin-cytological dissociation, and a nerve conduction study was done. The patient was managed by neuro physiotherapy 34 days after COVID-19 exposure. After proper physiotherapy and rehabilitation, the patient was able to return to his college life.