Background:Peptic ulcer is a global health problem of the gastrointestinal tract characterized by mucosal damage secondary to pepsin and gastric acid secretion which occurs due to due to an imbalance between offensive and defensive factors.Objective:The present study was carried out with methanolic extract of the seed coat of Tamarindus indica Linn. to evaluate its antiulcer potential on ibuprofen, alcohol and pyloric ligation induced gastric lesions.Materials and Methods:Doses of 100 mg/kg & 200 mg/kg of methanolic extract wre administered orally to rats of different groups. Ranitidine at a dose of 50 mg/kg was used as a standard drug for these gastric ulcer models. The gastric content was collected and the volume was measured. The ulceration index was determined by examining the inner lining of each stomach. Furthermore, the effect was assessed by free acidity, pepsin activity, total carbohydrate (TC), protein content (PK).Result:The result showed that the methanolic extract of seed coats of Tamarindus indica significantly reduce the total volume of gastric juice, free and total acidity of gastric secretion (P < 0.01) in pylorus ligation induced ulcer model as is comparable with the standard drug ranitidine. There was also a significant reduction in ulcer index (P < 0.01) as compared to control group.Conclusion:The methanolic extracts of seed coat of Tamarindus indica can be used as a new source of antiulcer agent in animals.

The central nervous system (CNS) pharmacological effects of ethylacetate extract (EAS) of Sida tiagii Bhandri collected from northern province (Rajasthan) of India were assessed by elevated plus-maze, pentobarbitone induced sleeping time, spontaneous motor activity, pentylenetetrazole-induced seizure, forced swim test and rotarod tests. The results of the present study demonstrated the CNS depressant potential, i.e., anxiolytic, antiseizure, reduction in spontaneous locomotion and potentiation of pentobarbital-induced hypnosis of the plant under investigation.

The present study was undertaken to investigate the effects of different fruit extracts of Sida tiagii Bhandari (Family: Malvaceae), popularly known as Kharinti, on depressive behaviors in mice using forced swim test (FST) and tail suspension test (TST). Extracts were prepared by partitioning of 90% alcoholic extract with n-hexane (HS) and ethyl acetate (EAS) successively and were administered orally for 20 successive days to separate groups of Swiss young male albino mice. HS showed a dose dependent effect on immobility period while residual ethanolic extract (RES) showed the most potent antidepressant effect at all three doses. Chronic administration of EAS showed a variable effect (ineffective in TST while reversal in FST) at 200 and 500 mg/kg doses. RES significantly reduced the immobility times of mice in both FST and TST, without any significant effect on locomotive activity at all doses (100, 200, 500 mg/kg). The efficacy of RES was found to be comparable to that of imipramine (15 mg