Investigations were suggestive of severe macrocytic hypochromic anaemia (Hb 6.4 gm%), RBC 2.48 mill/cmm, Mean corpuscular volume (MCV) 82 fl, Packed cell volume (PCV) 22.6%, Mean corpuscular hemoglobin (MCH) 26 pg, Mean corpuscular hemoglobin concentration (MCHC) 28.4%, Red blood cell distribution width (RDW) 26% with peripheral smear showing hypochromic macrocytic picture. Her serum calcium value was low (9.4 mg/dl), while Serum B12, Random Blood Sugar (RBS), serum TSH (Thyroid ABSTRACT Infantile tremor syndrome (ITS) is a clinical entity characterized by tremors, skin pigmentation, anemia, developmental and mental retardation. It is most commonly found in Indian subcontinent and in children who are exclusively on breast feeding of vegetarian mother. Amongst all the etiological theories, nutritional theory is the most accepted one. Management of ITS is largely empirical and includes therapy of nutritional deficiency, anemia & tremors apart from appropriate care. Treatment of nutritional deficiency includes vitamin B12, multivitamins, folic acid, iron, calcium, zinc, magnesium and high protein diet. In this article, three cases of ITS with classical picture have been reported.