Background and purpose Previous studies investigating cardiovascular disorders in patients with Parkinson's disease (PD) showed heterogeneous results regarding whether there is a higher or lower risk of myocardial infarction (MI) in these patients compared to the general population. Because of the inconsistency in findings, herein the aim was to perform a systematic review and meta‐analysis to investigate the risk of MI in patients with PD. Methods A comprehensive literature search was performed using four databases, PubMed, Web of Science, Scopus and Embase, in June 2022. Peer‐reviewed observational studies comprising case–controls, cohort, cross‐sectional and longitudinal studies that reported MI in the PD population were included. Results After the screening, 20 studies with a total of 80,441 patients with PD and 802,857 controls were included in our qualitative and quantitative synthesis. The pooled estimated odds ratio for MI in PD patients compared to controls was 0.80 (95% confidence interval [CI] 0.56–1.05) which indicates that there is no association. The pooled prevalence of MI was 5% (95% CI 3%–7%) with a range of 1%–20% amongst patients with PD. The men (6%, 95% CI 1%–13%) and women (6%, 95% CI 1%–14%, Q = 29.27, I2 = 98.50%, p < 0.001) had similar MI prevalence. Conclusion This comprehensive systematic review and meta‐analysis provide compelling evidence that PD is associated with a reduced risk of MI. Whilst the exact mechanism underlying this association remains to be fully elucidated, it is clear that certain risk factors for cardiac events appear to be less present in PD patients, which may serve as a protective factor. However, given the reports of increased risk for cerebrovascular events in PD patients, it is possible that the major risk factors for MI and cardiovascular accidents in this population differ. These findings have important implications for clinical management and further research in this area is warranted.

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The present work aims to study the drought stress effects on polyamine content and its relationship with growth and development in seeds, during cell division (from the beginning and until 17 days after pollination) and grain filling (until reaching the physiological maturity) stages. Factorial experiment based on Randomized Complete Block (RCB) design was carried out with three replications. Two factors of the experiment were considered: the level of irrigation (irrigation without and with drought stress during cell division stage and with drought stress during grain filling stage) and the level of wheat genotype (drought-resistant, semi-resistant and sensitive genotypes). As control treatment, soil moisture content of the field was considered. For droughtstress treatment, the 50% of the soil moisture content in control treatment was established. According to the experimental results, Putrescine content value is higher in control treatment which develops seeds of drought-resistant genotypes than that are registered for semi-resistant and sensitive genotypes. Both drought stress treatments induced significant rises in putrescine amount in the different genotypes of the study. The rises of putrescine content in sensitive and semi-resistant genotypes, however, were higher than in resistant ones, and the highest rise in putrescine content appeared in manning semi-resistant genotype during the stage of grain filling (27 days after pollination). Exerting

An experiment was conducted in split plots in a completely randomized block design with three replications to evaluate the impact of drought stress on physiological indices of maize growth and the effect of humic acid fertilizer on alleviating drought stress. The main factor included three irrigation levels of 100%, 75%, and 50% and sub-factor was the use and non-use of humic acid. The results showed that in all different levels of irrigation and humic acid treatments, the index of leaf area index (LAI), crop growth rate (CGR) and dry matter accumulation are sigmoid. The highest LAI was (4.5) and biological yield was (15.5 ha) in full irrigation treatment with humic acid, and minimum LAI was (3) with biological yield (8.8 tons per hectare) in 50% irrigation treatment and non-use of humic acid. The results showed that LAI and receiving light were the most important factor affecting the growth indices. Moreover, the highest and lowest CGR CGR, relative growth rate (RGR) RGR and net absorption rate (NAR) were related to full irrigation + consumption of humic acid and 50% irrigation and non-use of humic acid respectively. Overall, the results showed that in without stress treatment (irrigation 100%), the use of humic acid compared to non-use increased RGR, CGR, NAR and LAI at 1.3%, 21%, 8% and 12.5% respectively. This is while in water stress (irrigation 50%), humic acid consumption increased these indices 7%, 25%, 14% and 30% respectively representing a reduction drought stress by humic acid. In general, it could be argued that the use of humic acid, due to adjusting the drought, could have a positive role in water stress to reduce the use of chemical fertilizers, reducing environmental pollution, and to mitigate drought stress, and as is suggested a stable source of supplying nutrients in drought conditions for maize.

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