Mesoporous silica nanoparticles (MSNs) are widely used as a promising candidate for drug delivery applications due to silica’s favorable biocompatibility, thermal stability, and chemical properties. Silica’s unique mesoporous structure allows for effective drug loading and controlled release at the target site. In this review, we have discussed various methods of MSNs’ mechanism, properties, and its drug delivery applications. As a result, we came to the conclusion that more in vivo biocompatibility studies, toxicity studies, bio-distribution studies and clinical research are essential for MSN advancement.
The ultrasonic assisted reverse micelle method (UARM) was used to synthesize Cu-MOF from Cu(NO3)2·3H2O and 2,6-pyridine dicarboxylic acid in a 1:1 molar proportion. It has been characterized using FT-IR, XRD, nitrogen adsorption analysis, SEM and TEM–EDX. The morphology of Cu-MOFs was spherical, with an average particle size distribution of less than 100 nm. Using BET analysis, the surface area of Cu-MOF was found to be 284.94 m2/g. The porous morphology of Cu-MOF was also suggested by SEM and TEM analyses. It has anticancer properties against MCF-7 breast cancer cells. Cytotoxicity testing was performed on MCF-7 breast cancer cells using the MTT cell viability assay, and cell proliferation and viability were found to be approximately 24% higher than the control.
Different sources of carbon in the synthesis of silicon carbide were evaluated using a multiattribute group decision making fuzzy model. In this model, the aim was to find the carbon precursor which has the minimum price, highest carbon content, good water solubility, lowest synthesis temperature and the optimum crystallite size. Based on the model results, sugar was the best candidate. Therefore, sugar was selected as carbon source in the synthesis of SiC, also tetraethyl ortho-silicate (TEOS) used as source of Silicon. The XRD and SEM results showed that the SiC powder prepared by this method was fully crystalline and has the average crystallite size of 40 nm, and a flake-like morphology. The synthesis temperature was 800°C, which is a relatively low temperature for synthesis of crystalline SiC. To optimize the carbothermal process, microwave heating and just 15 minutes was enough to form crystalline SiC with this method.
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