Background:The guanine exchange factor Epac is a cAMP sensor. Results: We have identified a tetrahydroquinoline analog named CE3F4 that blocks Epac activation in response to cAMP in vitro and in living cultured cells. Conclusion: CE3F4 behaves as an uncompetitive antagonist of Epac with respect to cAMP. Significance: CE3F4 may serve as a basis for the development of new therapeutic drugs.
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