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Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of alternate intraperitoneal injections of LPS on BBB permeability, social recognition memory and biochemical parameters in the striatum 24 h and 60 days after treatments. In addition, we investigated whether the exposure to a moderate neurotoxic dose of the herbicide paraquat could potentiate LPS-induced neurotoxicity. LPS administration caused a transient disruption of BBB integrity, evidenced by increased levels of exogenously administered sodium fluorescein in the striatum. Also, LPS exposure caused delayed impairment in social recognition memory (evaluated at day 38 after treatments) and increase in the striatal levels of 3-nitrotyrosine. These events were observed in the absence of significant changes in motor coordination and in the levels of tyrosine hydroxylase (TH) in the striatum and substantia nigra. PQ exposure, which caused a long-lasting decrease of striatal mitochondrial complex I activity, did not modify LPS-induced behavioral and striatal biochemical changes. The results indicate that systemic administration of LPS causes delayed social recognition memory deficit and striatal nitrosative stress in adult mice and that the coexposure to a moderately toxic dose of PQ did not magnify these events. In addition, PQ-induced inhibition of striatal mitochondrial complex I was also not magnified by LPS exposure, indicating the absence of synergic neurotoxic effects of LPS and PQ in this experimental model.

No Brasil, apesar do acesso ao ensino ser um direito garantido em Lei, a inclusão de pessoas com deficiências no sistema educacional não está ocorrendo na velocidade necessária, seja por falta de recursos didáticos ou por falta de formação adequada dos educadores. O projeto de Extensão Democratização do ensino de ciências morfológicas: promovendo acessibilidade a pessoas com deficiências visuais visa pesquisar e desenvolver material didático adequado, de baixo custo e fácil reprodução, para o ensino de Biologia Celular e Histologia a deficientes visuais. As matrizes táteis, formas de representar estruturas com a utilização de materiais com diferentes texturas e relevos, foram as ferramentas didáticas escolhidas. Atualmente, matrizes táteis de várias células dos tecidos biológicos estão sendo confeccionadas e testadas. Os resultados obtidos serão divulgados com a publicação de um atlas de morfologia e a criação do sítio eletrônico do projeto.