RAFT-mediated self-condensing vinyl polymerization is a promising synthetic tool to create well-defined hyperbranched polymers.

We report the first synthesis of hyperbranched poly(N-(2-hydroxypropyl) methacrylamide) (HB-PHPMA) using reversible addition–fragmentation chain transfer (RAFT) self-condensing vinyl polymerization (SCVP).

Polyacrylamides containing pendant aminobisphosphonate groups are synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization and a multicomponent postpolymerization functionalization reaction. A Moedritzer-Irani reaction installs the phosphonic acid groups on well-defined, RAFT-generated polymers bearing a pendant amine. An alternate route to the same materials is developed utilizing a three-component Kabachnik-Fields reaction and subsequent dealkylation. Kinetics of the RAFT polymerization of the polymer precursor are studied. Successful functionalization is demonstrated by NMR and FTIR spectroscopy and elemental analysis of the final polymers.